Pang Yang, Xu Ye, Cheng Kuan, Chen Chaofeng, Chen Qingxing, Ling Yunlong, Liu Guijian, Ge Junbo, Zhu Wenqing
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, No.180, Feng-Lin Road, Shanghai, 200032, P.R. China.
J Interv Card Electrophysiol. 2025 Apr;68(3):709-720. doi: 10.1007/s10840-024-01974-w. Epub 2025 Jan 8.
Ventricular arrhythmia (VA) originating from the left ventricular summit (LVS) poses particular challenges, with higher rates of ablation failure.
To further evaluate the anatomical ablation approach from the subaortic region for LVS VAs and their electrophysiological characteristics.
The study enrolled 27 consecutive patients with sympatomatic VAs originating from LVS and who received an anatomical ablation approach from R-L ILT in our center.
Three different mapping results were obtained as the earliest activation sites (EAS) were observed in the RVOT region (group 1), R-L ILT (group 2), and epicardial region (group 3), respectively. A higher percentage of rS/QS patterns in lead I was observed in Groups 1 and 3. A narrower QRS duration was observed in Group (1) A presystolic potential was recorded at R-L ILT for most VAs in group (2) All VAs were successfully ablated at R-L ILT in groups 1 and 2, though poor pace mapping results were observed at R-L ILT. 4/7 VAs in group 3 ultimately failed after an ablation in both the endocardial and epicardial regions.
An anatomical ablation approach at R-L ILT was effective for most VAs with an LVS origin. Different ECG and electrophysiological characteristics could be observed in VAs with different EAS. Poor pace mapping results in all regions with an EAS in the epicardial region had predictive value for the failure of the ablation procedure.
起源于左心室嵴(LVS)的室性心律失常(VA)带来了特殊挑战,消融失败率较高。
进一步评估经主动脉下区域对LVS室性心律失常的解剖消融方法及其电生理特征。
本研究纳入了27例连续的有症状的起源于LVS的室性心律失常患者,他们在我们中心接受了经右-左间隔入路的解剖消融方法。
获得了三种不同的标测结果,最早激动部位(EAS)分别在右心室流出道区域(第1组)、右-左间隔(第2组)和心外膜区域(第3组)被观察到。第1组和第3组在I导联中观察到较高比例的rS/QS图形。第1组观察到较窄的QRS波时限。在第2组中,大多数室性心律失常在右-左间隔记录到收缩前期电位。第1组和第2组的所有室性心律失常在右-左间隔均成功消融,尽管在右-左间隔观察到较差的起搏标测结果。第3组的7例室性心律失常中有4例在心内膜和心外膜区域消融后最终失败。
经右-左间隔的解剖消融方法对大多数起源于LVS的室性心律失常有效。在具有不同最早激动部位的室性心律失常中可观察到不同的心电图和电生理特征。在心外膜区域有最早激动部位的所有区域起搏标测结果较差对消融手术失败具有预测价值。