二价金属离子转运体1在炎症性和退行性疾病中的作用。
The Roles of DMT1 in Inflammatory and Degenerative Diseases.
作者信息
Liu Haigang, Li Mi, Deng Yi, Hou Yanjun, Hou Liangcai, Zhang Xiong, Zheng Zehang, Guo Fengjing, Sun Kai
机构信息
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
出版信息
Mol Neurobiol. 2025 May;62(5):6317-6332. doi: 10.1007/s12035-025-04687-x. Epub 2025 Jan 7.
Iron homeostasis is critical for multiple physiological and pathological processes. DMT1, a core iron transporter, is expressed in almost all cells and organs and altered in response to various conditions, whereas, there is few reviews focusing on DMT1 in diseases associated with aberrant iron metabolism. Based on available knowledge, this review described a full view of DMT1 and summarized the roles of DMT1 and DMT1-mediated iron metabolism in the onset and development of inflammatory and degenerative diseases. This review also provided an overview of DMT1-related treatment in these disorders, highlighting its therapeutic potential in chronic inflammatory and degenerative diseases.
铁稳态对多种生理和病理过程至关重要。二价金属离子转运体1（DMT1）作为一种核心铁转运蛋白，几乎在所有细胞和器官中均有表达，并会随各种条件而发生变化，然而，很少有综述关注DMT1在铁代谢异常相关疾病中的作用。基于现有知识，本综述全面描述了DMT1，并总结了DMT1以及DMT1介导的铁代谢在炎症性和退行性疾病发生发展中的作用。本综述还概述了针对这些疾病的DMT1相关治疗方法，强调了其在慢性炎症性和退行性疾病中的治疗潜力。
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