Gurunathan Deepa, Pandiar Deepak, Krishnan Reshma Poothakulath
Department of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Eur Arch Paediatr Dent. 2025 Apr;26(2):225-232. doi: 10.1007/s40368-024-00987-3. Epub 2025 Jan 7.
Pre-eruptive intracoronal resorption (PIER) defects constitute an important part of anomalies associated with unerupted teeth. However, these defects are usually overlooked by clinicians whilst interpreting radiographs. This systematic review was thus orchestrated to find the global prevalence of PEIR.
A comprehensive database search was done until December 2022 for published articles on the prevalence of pre-eruptive intracoronal resorption following preferred reporting items for systematic reviews and meta-analyses guidelines. The review was registered in Prospero (CRD42024501668). The risk of bias was analysed for each study using the Newcastle-Ottawa Quality Assessment Scale for cross-sectional studies.
In total 18 studies were included in the present systematic review. The subject prevalence was 3.54% (range 0.56-27.31%) and tooth prevalence of 0.695% (Range 0.073-2.12%). Males and females were equally affected with no difference based on geography and race. Mandibular teeth showed more incidence of PEIR than maxillary teeth. First premolars were most frequently affected in the mandibular arch, whilst canines were affected most in the maxillary arch.
Within the limits of the review, we presented for the first time the global prevalence of PEIR. The condition may be overlooked and could lead to potential complications, thus it is essential to promptly diagnose these defects, thus preventing any further complications. We further suggest that all extirpated soft tissue should be submitted for further evaluation to shed light on the pathogenetic mechanisms involved in the initiation and progression of the disease.
萌出前牙内吸收（PIER）缺陷是与未萌出牙相关的异常情况的重要组成部分。然而，临床医生在解读X线片时通常会忽略这些缺陷。因此，本系统评价旨在找出PIER的全球患病率。
按照系统评价和Meta分析的首选报告项目指南，对截至2022年12月发表的关于萌出前牙内吸收患病率的文章进行了全面的数据库检索。该评价已在国际前瞻性系统评价注册库（Prospero）中注册（注册号：CRD42024501668）。使用横断面研究的纽卡斯尔-渥太华质量评估量表对每项研究的偏倚风险进行分析。
本系统评价共纳入18项研究。受试者患病率为3.54%（范围0.56%-27.31%），牙齿患病率为0.695%（范围0.073%-2.12%）。男性和女性受影响程度相同，不受地理和种族影响。下颌牙的PIER发生率高于上颌牙。下颌牙弓中第一前磨牙受影响最频繁，而上颌牙弓中尖牙受影响最严重。
在本评价的范围内，我们首次呈现了PIER的全球患病率。这种情况可能被忽视并可能导致潜在并发症，因此及时诊断这些缺陷至关重要，从而预防任何进一步的并发症。我们进一步建议，所有切除的软组织都应送检以进一步评估，以阐明该疾病发生和发展所涉及的发病机制。
