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Psychiatric comorbidities, inflammatory bowel disease, and urticaria in acne vulgaris patients undergoing isotretinoin treatment: a multicenter cohort study from the TriNetX database.

作者信息

Verma Kritin K, Koch Ryan S, Friedmann Daniel P, Tarbox Michelle B, Tyring Stephen K

机构信息

School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430, USA.

Texas A&M University College of Medicine, Dallas, TX, USA.

出版信息

Arch Dermatol Res. 2025 Jan 7;317(1):183. doi: 10.1007/s00403-024-03743-1.

DOI:10.1007/s00403-024-03743-1
PMID:39775941
Abstract
摘要

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Psychiatric comorbidities, inflammatory bowel disease, and urticaria in acne vulgaris patients undergoing isotretinoin treatment: a multicenter cohort study from the TriNetX database.接受异维A酸治疗的寻常痤疮患者的精神共病、炎症性肠病和荨麻疹：一项来自TriNetX数据库的多中心队列研究
Arch Dermatol Res. 2025 Jan 7;317(1):183. doi: 10.1007/s00403-024-03743-1.
2
A propensity score matched cohort study identifying an association of acne, but not oral antibiotic or isotretinoin use, with risk of incident inflammatory bowel disease.一项倾向评分匹配队列研究表明，痤疮与炎症性肠病发病风险相关，而口服抗生素或异维 A 酸的使用与该风险无关。
J Am Acad Dermatol. 2023 Apr;88(4):841-847. doi: 10.1016/j.jaad.2023.01.014. Epub 2023 Jan 20.
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Psychiatric disorders and suicidal behavior in patients with acne prescribed oral antibiotics versus isotretinoin: Analysis of a large commercial insurance claims database.口服抗生素与异维A酸治疗痤疮患者的精神障碍和自杀行为：大型商业保险理赔数据库分析
J Am Acad Dermatol. 2021 Oct;85(4):878-884. doi: 10.1016/j.jaad.2021.01.107. Epub 2021 Mar 13.
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Clarifying the Purported Association between Isotretinoin and Inflammatory Bowel Disease.澄清异维A酸与炎症性肠病之间所谓的关联。
J Environ Health Sci. 2015;1(2). doi: 10.15436/2378-6841.15.007.
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Isotretinoin and the risk of inflammatory bowel disease and irritable bowel syndrome: A large-scale global study.异维A酸与炎症性肠病和肠易激综合征的风险：一项大规模全球研究。
J Am Acad Dermatol. 2023 Apr;88(4):824-830. doi: 10.1016/j.jaad.2022.12.015. Epub 2022 Dec 15.
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Risk of psychiatric disorders in patients taking isotretinoin: A nationwide, population-based, cohort study in Taiwan.台湾一项全国性基于人群的队列研究：异维 A 酸治疗患者的精神障碍发病风险。
J Affect Disord. 2022 Jan 1;296:277-282. doi: 10.1016/j.jad.2021.09.055. Epub 2021 Sep 22.
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Risk of new-onset inflammatory bowel disease among patients with acne vulgaris exposed to isotretinoin.异维 A 酸暴露的痤疮患者新发炎症性肠病的风险。
J Am Acad Dermatol. 2021 Jan;84(1):41-45. doi: 10.1016/j.jaad.2020.07.042. Epub 2020 Jul 17.
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Antibiotics used to treat acne may be associated with inflammatory bowel disease: Response to Kridin et al "Isotretinoin and the risk of inflammatory bowel disease and irritable bowel syndrome: A large-scale global study".用于治疗痤疮的抗生素可能与炎症性肠病有关：对克里丁等人《异维A酸与炎症性肠病和肠易激综合征风险：一项大规模全球研究》的回应
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Isotretinoin and the risk of psychiatric disturbances: A global study shedding new light on a debatable story.异维 A 酸与精神障碍风险：一项为有争议故事提供新视角的全球研究。
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Important controversies associated with isotretinoin therapy for acne.与痤疮异维 A 酸治疗相关的重要争议。
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Cureus. 2025 Jul 2;17(7):e87177. doi: 10.7759/cureus.87177. eCollection 2025 Jul.

本文引用的文献

1
A retrospective case-control analysis of various comorbidities associated with Merkel Cell Carcinoma.默克尔细胞癌相关各种合并症的回顾性病例对照分析。
Arch Dermatol Res. 2024 Jun 8;316(7):355. doi: 10.1007/s00403-024-03026-9.
2
Isotretinoin Exposure and Risk of Inflammatory Bowel Disease: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.异维 A 酸暴露与炎症性肠病风险：系统评价与荟萃分析和试验序贯分析。
Am J Clin Dermatol. 2023 Sep;24(5):721-730. doi: 10.1007/s40257-023-00765-9. Epub 2023 Apr 3.
3
Angioedema and urticaria due to isotretinoin therapy.
异维A酸治疗引起的血管性水肿和荨麻疹。
J Eur Acad Dermatol Venereol. 2006 Jan;20(1):118-20. doi: 10.1111/j.1468-3083.2005.01350.x.