Hutchinson I V, Roman J, Bonavida B
Adv Exp Med Biol. 1979;121B:553-62. doi: 10.1007/978-1-4684-8914-9_49.
Radiolabelled antitumor reactive T lymphocytes (ARC) were prepared in vivo by immunization of SJL/J mice with mitomycin C inactivated syngeneic LA-6 tumor cells followed by injection of 125IUdR to label dividing cells. These ARC were specifically diverted to the liver when injected in LA-6 tumor-bearer serum and injected i.v. into normal SJL/J mice. Likewise, SJL/J anti-Balb/c ARC were diverted to the liver of SJL/J mice bearing spontaneous reticulum cell sarcomas (RCS) carrying Balb/c cross-reactive antigens but not in mice with Balb/c negative neoplasms. Mice with Balb/c positive tumors also had circulating ARC opsonizing factors. These results suggest a mechanism for the survival of antigenic tumors involving macrophages and ARC opsonizing (ARCO) factors. A novel approach to immunotherapy is discussed.
通过用丝裂霉素C灭活的同基因LA - 6肿瘤细胞免疫SJL/J小鼠，随后注射125IUdR标记分裂细胞，在体内制备放射性标记的抗肿瘤反应性T淋巴细胞（ARC）。当将这些ARC注射到LA - 6荷瘤血清中并静脉注射到正常SJL/J小鼠体内时，它们会特异性地转移至肝脏。同样，SJL/J抗Balb/c ARC会转移至携带Balb/c交叉反应性抗原的自发网状细胞肉瘤（RCS）的SJL/J小鼠肝脏中，但不会转移至Balb/c阴性肿瘤的小鼠肝脏中。具有Balb/c阳性肿瘤的小鼠也具有循环ARC调理因子。这些结果提示了一种涉及巨噬细胞和ARC调理（ARCO）因子的抗原性肿瘤存活机制。本文讨论了一种免疫治疗的新方法。
