McSorley Brianna, Plunk Matthew, Challa Sai Alekha, Pan Amy Y, Noe Joshua
Pediatric Gastroenterology, Medical College of Wisconsin, B610 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Children's Wisconsin, Milwaukee, USA.
Pediatr Radiol. 2025 Apr;55(4):857-864. doi: 10.1007/s00247-024-06129-7. Epub 2025 Jan 7.
Quantitative magnetic resonance imaging (MRI) can evaluate bowel motility in children with Crohn's disease. As inflammation increases, motility decreases.
Our aim was to show that quantitative MRI correlates with magnetic resonance enterography (MRE). We hypothesize that the motility score will inversely correlate with the Endoscopic Biopsy Acute Histologic Inflammatory Score (eAIS), the Crohn's Disease Endoscopic Index of Severity (CDEIS) score, and the MR Index of Activity (MaRIA) score.
This was a retrospective study of 50 pediatric patients with ileal and/or cecal Crohn's disease who underwent endoscopy and MRE within 7 days of each other without exposure to therapy. Cine images were used from patients' previously obtained MREs to obtain a motility score using GIQuant (Motilent, London, UK). The relationships between the motility score and MaRIA, eAIS, and CDEIS were then calculated by Spearman's rank correlation coefficient (ρ).
The MaRIA and motility scores inversely correlated (ρ=-0.66, 95%CI (-0.79, -0.46), P<0.0001). MaRIA positively correlated with CDEIS (ρ=0.30, 95%CI (0.02, 0.53), P=0.03) and eAIS (ρ=0.26, 95%CI (0.02, 0.50), P=0.07). The motility score showed a non-significant negative correlation with CDEIS (ρ=-0.17, 95%CI (-0.43, -0.12), P=0.24) and eAIS (ρ=-0.23, 95%CI (-0.48, -0.05), P=0.11).
Quantitative MRI correlates with standard MRE in identifying inflammation of the bowel in Crohn's disease. The cine image used to produce a motility score is obtained faster than standard MRE and does not require the use of intravenous contrast, a spasmolytic agent, and breath-holding techniques.
定量磁共振成像（MRI）可评估克罗恩病患儿的肠道蠕动情况。随着炎症加剧，蠕动会减弱。
我们的目的是证明定量MRI与磁共振小肠造影（MRE）相关。我们假设蠕动评分将与内镜活检急性组织学炎症评分（eAIS）、克罗恩病内镜严重程度指数（CDEIS）评分以及磁共振活动指数（MaRIA）评分呈负相关。
这是一项对50例患有回肠和/或盲肠克罗恩病的儿科患者进行的回顾性研究，这些患者在7天内相继接受了内镜检查和MRE，且未接受治疗。使用患者之前获得的MRE的电影图像，通过GIQuant（Motilent，英国伦敦）获得蠕动评分。然后通过斯皮尔曼等级相关系数（ρ）计算蠕动评分与MaRIA、eAIS和CDEIS之间的关系。
MaRIA与蠕动评分呈负相关（ρ=-0.66，95%置信区间（-0.79，-0.46），P<0.0001）。MaRIA与CDEIS呈正相关（ρ=0.30，95%置信区间（0.02，0.53），P=0.03），与eAIS呈正相关（ρ=0.26，95%置信区间（0.02，0.50），P=0.07）。蠕动评分与CDEIS呈非显著负相关（ρ=-0.17，95%置信区间（-0.43，-0.仁），P=0.24），与eAIS呈非显著负相关（ρ=-0.23，95%置信区间（-0.48，-（）.05），P=0.11）。
在识别克罗恩病肠道炎症方面，定量MRI与标准MRE相关。用于产生蠕动评分的电影图像比标准MRE获取速度更快，且无需使用静脉造影剂、解痉剂和屏气技术。
