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一种新型水合结晶形式的 -[()-(4-羟基-苯基)亚甲基]-1,2,4-三唑-3-胺及其抗真菌活性。

A new hydrated crystalline form of -[()-(4-hy-droxy-phen-yl)methyl-idene]-1-1,2,4-triazol-3-amine and its anti-fungal activity.

作者信息

Boutheina Boualia, Zakaria Bouhidel, Cherouana Aouatef, El-Eulmi Bendeif

机构信息

Unité de Recherche de Chimie de l'Environnement et Moléculaire Structurale (URCHEMS) Département de Chimie Université Mentouri de Constantine 25000 Constantine Algeria.

Synchrotron SOLEIL, L'Orme des Merisiers, BP48, Saint Aubin, 91192, Gif-sur-Yvette, France.

出版信息

Acta Crystallogr E Crystallogr Commun. 2025 Jan 1;81(Pt 1):80-84. doi: 10.1107/S205698902401209X.

DOI:10.1107/S205698902401209X
PMID:39776630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11701766/
Abstract

The synthesis, crystal structure, Hirshfeld analysis, and anti-fungal assessment of a new monohydrated Schiff base with a triazole moiety are reported. The structural study revealed the presence of three significant hydrogen bonds (N-H⋯N, O-H⋯N, and O-H⋯O), which contribute to the cohesion of the crystal. These bonds generate two-dimensional layers parallel to the plane, built on the basis of rings with the graph-set motifs (8) and (24). The crystal structure is further consolidated by π-π inter-actions between similar rings. The anti-fungal activity of the Schiff base was evaluated against three fungi: , , and , showing significant anti-fungal activity, particularly against .

摘要

报道了一种含三唑部分的新型一水合席夫碱的合成、晶体结构、 Hirshfeld分析和抗真菌评估。结构研究表明存在三种重要的氢键（N-H⋯N、O-H⋯N和O-H⋯O），这有助于晶体的凝聚。这些键形成平行于 平面的二维层，基于具有图集模式 (8)和 (24)的环构建。晶体结构通过相似环之间的π-π相互作用进一步巩固。评估了席夫碱对三种真菌： 、 和 的抗真菌活性，显示出显著的抗真菌活性，特别是对 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/e0b8b82301db/e-81-00080-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/6db6ee20d2ab/e-81-00080-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/8aa026e3870e/e-81-00080-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/bbaac65fd45e/e-81-00080-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/f101f01857e1/e-81-00080-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/3848fdc3b31c/e-81-00080-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/56a71468698e/e-81-00080-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/cbcca1e8fa0d/e-81-00080-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/e0b8b82301db/e-81-00080-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/6db6ee20d2ab/e-81-00080-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/8aa026e3870e/e-81-00080-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/bbaac65fd45e/e-81-00080-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/f101f01857e1/e-81-00080-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/3848fdc3b31c/e-81-00080-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/56a71468698e/e-81-00080-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/cbcca1e8fa0d/e-81-00080-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da2/11701766/e0b8b82301db/e-81-00080-fig8.jpg

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