Chen Lina, Qiu Canhu, Lu Ye, Lin Jianqing, Xu Liping
Department of Critical Care Medicine, Jiangshan People's Hospital, Quzhou, People's Republic of China.
Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Infect Drug Resist. 2025 Jan 3;18:43-49. doi: 10.2147/IDR.S489161. eCollection 2025.
Hypervirulent (hvKp) has attracted increasing attention in recent years. Diabetes and serotype K1 or K2 are risk factors for invasive liver abscess syndrome including liver abscesses and the metastatic complications such as bacteremia, meningitis, endophthalmitis, and necrotizing fasciitis. Simultaneous infections of the liver, lungs, prostate, brain, and eyes are exceedingly rare. In this paper, a 41-year-old male patient who presented with a 4-day history of fever with polydipsia and polyuria and untreated diabetes deteriorated dramatically with sepsis, prostate abscess, lung abscess, liver abscess and intracranial infection as well as endophthalmitis. He was diagnosed with infection by K1/ST1265 hypervirulent and after treatment with antibiotics and abscess drainage, while the patient still passed away. K1/ST1265 hvKp exhibits exceptionally high virulence and invasiveness, necessitating broad awareness and vigilant monitoring.
近年来，高毒力肺炎克雷伯菌（hvKp）已引起越来越多的关注。糖尿病以及K1或K2血清型是侵袭性肝脓肿综合征的危险因素，该综合征包括肝脓肿以及诸如菌血症、脑膜炎、眼内炎和坏死性筋膜炎等转移性并发症。肝脏、肺、前列腺、脑和眼同时发生感染极为罕见。本文报告了一名41岁男性患者，有4天发热伴多饮、多尿病史，未治疗的糖尿病因脓毒症、前列腺脓肿、肺脓肿、肝脓肿、颅内感染以及眼内炎而急剧恶化。他被诊断为感染K1/ST1265高毒力肺炎克雷伯菌，经抗生素治疗和脓肿引流后，患者仍死亡。K1/ST1265 hvKp表现出极高的毒力和侵袭性，需要广泛关注并进行密切监测。
