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托法替布治疗类风湿关节炎伴局灶性肌炎的有效策略:一例报告

An effective strategy with tofacitinib for the management of focal myositis with rheumatoid arthritis: a case report.

作者信息

Pan Jing, Zheng Haihong, Xu Juan, Pan Shaobiao

机构信息

Department of Rheumatology and Immunology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

Department of Interventional Centers, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

出版信息

Front Immunol. 2024 Dec 24;15:1502410. doi: 10.3389/fimmu.2024.1502410. eCollection 2024.

Abstract

Focal myositis is a rare, localized, benign, self-limiting, and non-suppurative inflammatory lesion of the skeletal muscle that may occasionally occur as a complication of rheumatic diseases. This case report discusses a 58-year-old patient with rheumatoid arthritis, who was diagnosed with focal myositis during standard immunosuppressive therapy. The patient was treated with tofacitinib; to our knowledge, this is the first reported case of focal myositis managed with this medication. Clinicians should maintain a suspicion for focal myositis in patients presenting with localized muscle swelling and pain, especially those with underlying rheumatic conditions. In cases where corticosteroid tapering proves difficult, tofacitinib may be considered as an alternative therapeutic strategy.

摘要

局灶性肌炎是一种罕见的、局限性的、良性的、自限性的、非化脓性的骨骼肌炎性病变,偶尔可作为风湿性疾病的并发症出现。本病例报告讨论了一名58岁的类风湿关节炎患者,该患者在标准免疫抑制治疗期间被诊断为局灶性肌炎。该患者接受了托法替布治疗;据我们所知,这是首例报道使用该药物治疗局灶性肌炎的病例。临床医生应对出现局部肌肉肿胀和疼痛的患者,尤其是患有潜在风湿性疾病的患者,保持对局灶性肌炎的怀疑。在糖皮质激素减量困难的情况下,可考虑将托法替布作为一种替代治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e92/11703955/29998214f013/fimmu-15-1502410-g001.jpg

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