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4-[(2-羟乙基)氨基]-2-(4-甲氧基苯基)-1-甲基-5-氧代-2,5-二氢-1-吡咯-3-羧酸乙酯

Ethyl 4-[(2-hy-droxy-eth-yl)amino]-2-(4-meth-oxyphen-yl)-1-methyl-5-oxo-2,5-di-hydro-1-pyrrole-3-carboxyl-ate.

作者信息

Abdul Rashid Fatin Nur Ain, Mohammat Mohd Fazli, Abdul Manan Mohd Abdul Fatah, Bakhtiar Afendy Ayisy Amirul Afti, Cordes David B, McKay Aidan P

机构信息

Centre of Chemical Synthesis & Polymer Technology Institute of Science Universiti Teknologi MARA Puncak Alam 42300 Puncak Alam Selangor Malaysia.

Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

出版信息

IUCrdata. 2024 Dec 20;9(Pt 12):x241222. doi: 10.1107/S2414314624012227. eCollection 2024 Dec.

DOI:10.1107/S2414314624012227
PMID:39777006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11701760/
Abstract

In the title compound, CHNO the pyrrolidine ring is almost planar and subtends a dihedral angle of 85.77 (7)° with the pendant phenyl ring. An intra-molecular N-H⋯O hydrogen bond generates an (6) loop. In the crystal, the compound forms inversion dimers through O-H⋯O hydrogen bonds from the disordered hydroxyl group to either the hydroxyl or ester carbonyl O atom of the adjacent mol-ecule.

摘要

在标题化合物CHNO中，吡咯烷环几乎呈平面状，与悬垂的苯环形成85.77 (7)°的二面角。分子内N-H⋯O氢键形成一个(6)环。在晶体中，该化合物通过无序羟基与相邻分子的羟基或酯羰基O原子之间的O-H⋯O氢键形成反演二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11701760/cdc776538c5d/x-09-x241222-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11701760/168c4ffa337e/x-09-x241222-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11701760/cdc776538c5d/x-09-x241222-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11701760/168c4ffa337e/x-09-x241222-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11701760/cdc776538c5d/x-09-x241222-fig2.jpg

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Phytochemistry. 2022 Apr;196:113082. doi: 10.1016/j.phytochem.2021.113082. Epub 2022 Jan 17.
2
Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian .来源于夏威夷的抗菌和 NF-κB 抑制色氨酸肽、无柄小冠草素、γ-丁内酯衍生物和环肽
J Nat Prod. 2020 Jul 24;83(7):2233-2240. doi: 10.1021/acs.jnatprod.0c00344. Epub 2020 Jun 22.
3
: from visualization to analysis, design and prediction.
从可视化到分析、设计与预测。
J Appl Crystallogr. 2020 Feb 1;53(Pt 1):226-235. doi: 10.1107/S1600576719014092.
4
Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research.乳胞素：首屈一指的蛋白酶体抑制剂，依然卓越非凡，堪称未来抗生素研究的典范。
J Antibiot (Tokyo). 2019 Apr;72(4):189-201. doi: 10.1038/s41429-019-0141-8. Epub 2019 Feb 12.