Wu Zhiping, Zou Yun, Fu Ronghua, Cheng Jun, Bai Hanxiang, Huang Mengyu, Yuan Hua
Department of Plastic Surgery, Jiangxi Provincial Children's Hospital, Nanchang, China.
Front Cell Dev Biol. 2024 Dec 24;12:1490351. doi: 10.3389/fcell.2024.1490351. eCollection 2024.
Over the past few decades, percutaneous sclerotherapy has been proven to be efficacy in treating macrocystic lymphatic malformations (LMs). Unfortunately, there still remains challenging in the treatment of microcystic LMs given their size. We introduce the intralesional laser thermolysis (ILT) technique, a novel enhancement technique for the traditional percutaneous sclerotherapy in the treatment of microcystic LMs.
A retrospective analysis of children with microcystic LMs treated using ILT combined with percutaneous sclerotherapy was done. All patients underwent clinically and cross-sectional imaging to assess response to treatment.
Between January 2020 and April 2022, 16 consecutive patients (female/male ratio: 7:9; average age, 32.6 months; range: 6 months to 16 years) with microcystic LMs received treatment with ILT combined with percutaneous sclerotherapy. A total of twenty-six sessions of combination therapy were performed, with a mean number of sessions per patient of 1.6 (±0.7), ranging from 1 to 3 sessions. The follow-up time ranged from 6 to 24 months, with a mean of 15.8 (±6.3) months. Almost all patients showed significant improvement after the combination therapy. No major complications were observed. Minor complications included circumscribed skin blisters, postoperative non-infectious fever, transient skin edema, pigmentation, and slight depressions of localized skin.
The treatment of intralesional laser thermolysis combined with traditional sclerotherapy is considered as a safe, feasible and effective therapy in treating microcystic LMs.
在过去几十年中，经皮硬化治疗已被证明在治疗大囊型淋巴管畸形（LMs）方面有效。不幸的是，由于微囊型LMs的大小，其治疗仍然具有挑战性。我们引入了病灶内激光热解（ILT）技术，这是一种用于传统经皮硬化治疗微囊型LMs的新型增强技术。
对采用ILT联合经皮硬化治疗的微囊型LMs患儿进行回顾性分析。所有患者均接受临床和横断面成像以评估治疗反应。
在2020年1月至2022年4月期间，16例连续的微囊型LMs患者（女性/男性比例：7:9；平均年龄32.6个月；范围：6个月至16岁）接受了ILT联合经皮硬化治疗。共进行了26次联合治疗，每位患者的平均治疗次数为1.6（±0.7）次，范围为1至3次。随访时间为6至24个月，平均为15.8（±6.3）个月。几乎所有患者在联合治疗后均有显著改善。未观察到重大并发症。轻微并发症包括局限性皮肤水疱、术后非感染性发热、短暂性皮肤水肿、色素沉着和局部皮肤轻度凹陷。
病灶内激光热解联合传统硬化治疗被认为是治疗微囊型LMs的一种安全、可行且有效的疗法。
