Handlers J P, Waterman J, Abrams A M, Melrose R J
Arch Otolaryngol. 1985 Apr;111(4):267-70. doi: 10.1001/archotol.1985.00800060091015.
A review of the dental literature yielded ten cases of Wegener's granulomatosis manifesting in the oral cavity, but only one was found in the medical literature. The most common oral lesion is hyperplastic gingiva, which is red to purple, with many petechiae. Tooth mobility, loss of teeth, and failure of wounds to heal are also common manifestations. The disease may remain localized in the oral cavity for unusually long periods of time before multiorgan involvement occurs. Histologically, oral biopsy tissue does not exhibit the characteristic features of vasculitis and granulomas. There are, however, diagnostic histologic features that are consistently present, including pseudoepitheliomatous hyperplasia, epithelioid histiocytes, giant cells, and eosinophils. Failure to recognize these diagnostic clinical and histologic features resulted in a 24-month delay in the diagnosis and treatment of our patient.
对牙科文献的回顾发现有10例韦格纳肉芽肿病在口腔表现，但医学文献中仅发现1例。最常见的口腔病变是增生性牙龈，呈红色至紫色，有许多瘀点。牙齿松动、牙齿脱落和伤口愈合不良也是常见表现。该疾病在多器官受累之前可能会在口腔局部持续异常长的时间。组织学上，口腔活检组织未表现出血管炎和肉芽肿的特征性表现。然而，存在始终出现的诊断性组织学特征，包括假上皮瘤样增生、上皮样组织细胞、巨细胞和嗜酸性粒细胞。未能识别这些诊断性临床和组织学特征导致我们的患者诊断和治疗延迟了24个月。
