Barnhart M I, Lusher J M
Am J Pediatr Hematol Oncol. 1979 Winter;1(4):311-30.
The structural physiology of the human spleen is discussed in depth here, with particular emphasis on the interrelationships between blood cells and the spleen. The unique microvasculature and structural relationships of the spleen form the basis for a number of functions important in both health and disease. Utilizing scanning electron microscopy one can visualize the interactions between blood elements and the spleen---the passage of deformable erythrocytes through narrow slits in the endothelium separating cord and sinus, the trapping of less deformable cells in the cords, the culling and pitting of abnormal or inclusion-bearing erythrocytes by splenic macrophages, as well as the sites of interaction between antigenic stimuli such as pneumococcal organisms and the T and B cells of the spleen.
本文深入探讨了人类脾脏的结构生理学，特别强调了血细胞与脾脏之间的相互关系。脾脏独特的微血管系统和结构关系构成了许多在健康和疾病中都很重要的功能基础。利用扫描电子显微镜可以观察到血液成分与脾脏之间的相互作用——可变形红细胞通过分隔红髓索和血窦的内皮细胞狭窄缝隙的过程、较不易变形的细胞在红髓索中的滞留、脾巨噬细胞对异常或含有包涵体的红细胞的筛选和去核，以及抗原刺激物（如肺炎球菌）与脾脏T细胞和B细胞之间的相互作用位点。
