Kashimura M, Shibata A
Rinsho Ketsueki. 1989 Aug;30(8):1234-8.
Tissue blocks and vascular casts of the human spleen were studied by scanning electron microscopy. Splenic pulp was composed of white pulp packed with lymphocytes and red pulp which consisted of three dimensional reticular meshwork and splenic sinus. There were at least three types of microcirculation with different functions in the human spleen. First, open circulation in the red pulp is engaged in highly sensitive clearance of foreign materials in blood by numerous macrophages resided in splenic cord (culling function). It is also engaged in pitting function by narrow slits of the sinus. The second is the closed circulation occurred in the red pulp in the human spleen. It was represented as an arteriolar labyrinth whose endothelial cells connected with those of sinuses. Blood flow through this circulation is exposed to small number of macrophages in the sinus. It probably corresponds to the fast blood flow in the spleen. Third, microcirculation to the white pulp and marginal zone is engaged in phagocytosis of foreign materials in blood and carriage of their antigenic portions to lymphocytes in the white pulp. Therefore variation of the blood flow through their circulation may bring about a change of the splenic function. Relationship among blood flow, nerve stimulation and immune reaction was discussed.
通过扫描电子显微镜对人脾脏的组织块和血管铸型进行了研究。脾髓由充满淋巴细胞的白髓和由三维网状网络及脾窦组成的红髓构成。人脾脏中至少存在三种具有不同功能的微循环。首先，红髓中的开放循环通过位于脾索中的大量巨噬细胞参与血液中异物的高度敏感清除（筛选功能）。它还通过窦的狭窄缝隙参与去核功能。第二种是在人脾脏红髓中发生的封闭循环。它表现为一个小动脉迷路，其内皮细胞与窦的内皮细胞相连。通过这种循环的血流会接触到窦中少量的巨噬细胞。它可能对应于脾脏中的快速血流。第三种，到白髓和边缘区的微循环参与血液中异物的吞噬作用，并将其抗原部分传递给白髓中的淋巴细胞。因此，通过它们循环的血流变化可能会导致脾功能的改变。讨论了血流、神经刺激和免疫反应之间的关系。
