Dimitrion Peter M, Krevh Rachel, Veenstra Jesse, Ge James, Siddiqui Aamir, Ferguson Deangelo, Hans Aakash, Zuniga Bobby, Sidhu Kermanjot, Daveluy Steven, Hamzavi Iltefat, Zhou Li, Adrianto Indra, Mi Qing-Sheng
Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, USA.
Br J Dermatol. 2025 May 19;192(6):1063-1071. doi: 10.1093/bjd/ljaf012.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with a greater prevalence and disease burden in patients who identify as African American and those with a family history of HS, suggesting a strong genetic component to its pathogenesis.
To evaluate the relationship between plasma inflammatory protein expression, HS disease severity and genetic ancestry in a diverse cohort of patients with HS.
We performed a case-control, single-centre study of patients with HS and age-, sex- and ethnicity-matched healthy control participants. We profiled circulating inflammatory proteins using Olink® high-throughput proteomics and determined genetic ancestry from whole-genome sequencing data.
Using linear regression, we identified novel proteins associated with HS, after adjusting for age, sex and ethnicity. Our analysis also revealed differences in the inflammatory proteome linked to disease severity. Specifically, we found that plasma levels of interleukin (IL)-6 can distinguish between different Hurley stages, indicating that IL-6 may serve as a marker of disease severity. Additionally, we found variations in inflammatory protein levels based on genetic ancestry: patients with predominantly African ancestry exhibited higher levels of inflammatory proteins associated with neutrophilic inflammation, while those with predominantly European ancestry showed increased levels of T helper 1-related inflammatory proteins.
Although we were unable to account for treatment status or comorbidities that may influence the level of inflammatory cytokines, genetic ancestry and disease severity may influence the plasma inflammatory profile in patients with HS.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，在非裔美国人以及有HS家族史的患者中发病率和疾病负担更高，这表明其发病机制有很强的遗传成分。
在不同队列的HS患者中评估血浆炎症蛋白表达、HS疾病严重程度与遗传血统之间的关系。
我们对HS患者以及年龄、性别和种族匹配的健康对照参与者进行了一项单中心病例对照研究。我们使用Olink®高通量蛋白质组学分析循环炎症蛋白，并从全基因组测序数据中确定遗传血统。
通过线性回归，在调整年龄、性别和种族后，我们确定了与HS相关的新蛋白质。我们的分析还揭示了与疾病严重程度相关的炎症蛋白质组的差异。具体而言，我们发现白细胞介素（IL）-6的血浆水平可以区分不同的Hurley分期，这表明IL-6可能作为疾病严重程度的标志物。此外，我们发现基于遗传血统的炎症蛋白水平存在差异：主要为非洲血统的患者表现出与中性粒细胞炎症相关的炎症蛋白水平较高，而主要为欧洲血统的患者则表现出辅助性T细胞1相关炎症蛋白水平升高。
尽管我们无法考虑可能影响炎症细胞因子水平的治疗状态或合并症，但遗传血统和疾病严重程度可能会影响HS患者的血浆炎症谱。
