大鼠体内的亮氨酸和色氨酸代谢
Leucine and tryptophan metabolism in rats.
作者信息
Salter M, Bender D A, Pogson C I
出版信息
Biochem J. 1985 Jan 15;225(2):277-81. doi: 10.1042/bj2250277.
Abstract
The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.
摘要
在以高亮氨酸饮食喂养的动物的分离肝细胞中，色氨酸代谢速率高于对照动物的细胞。亮氨酸可能通过竞争膜转运来抑制分离肝细胞中的色氨酸代谢和色氨酸摄取。亮氨酸在体外对色氨酸2,3-双加氧酶没有影响。在含有白蛋白的孵育体系中，4-甲基-2-氧代戊酸通过取代结合的色氨酸并增加细胞对该氨基酸的可利用性，从而增加色氨酸氧化。结果表明，在极端条件下，当色氨酸可利用性较低时，亮氨酸可能具有致糙皮病性。
相似文献
1
Leucine and tryptophan metabolism in rats.大鼠体内的亮氨酸和色氨酸代谢
Biochem J. 1985 Jan 15;225(2):277-81. doi: 10.1042/bj2250277.
2
The metabolism of L-tryptophan by isolated rat liver cells. Effect of albumin binding and amino acid competition on oxidatin of tryptophan by tryptophan 2,3-dioxygenase.大鼠离体肝细胞对L-色氨酸的代谢。白蛋白结合及氨基酸竞争对色氨酸2,3-双加氧酶氧化色氨酸的影响。
Biochem J. 1980 Mar 15;186(3):977-86. doi: 10.1042/bj1860977.
3
4
Effect of 4-hydroxypyrazole on tryptophan and formate metabolism in isolated rat liver cells.4-羟基吡唑对离体大鼠肝细胞中色氨酸和甲酸代谢的影响。
Biochem J. 1982 Apr 15;204(1):307-12. doi: 10.1042/bj2040307.
5
Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.补充L-亮氨酸的饮食对大鼠肝脏烟酰胺腺嘌呤二核苷酸含量的影响。
J Nutr. 1982 Sep;112(9):1688-95. doi: 10.1093/jn/112.9.1688.
6
The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes.色氨酸2,3-双加氧酶在离体大鼠肝细胞色氨酸代谢激素调控中的作用。糖皮质激素和实验性糖尿病的影响。
Biochem J. 1985 Jul 15;229(2):499-504. doi: 10.1042/bj2290499.
7
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Br J Nutr. 1989 May;61(3):629-40. doi: 10.1079/bjn19890150.
8
The metabolism of L-tryptophan by liver cells prepared from adrenalectomized and streptozotocin-diabetic rats.由肾上腺切除和链脲佐菌素诱导糖尿病大鼠制备的肝细胞对L-色氨酸的代谢
Biochem J. 1981 Dec 15;200(3):605-9. doi: 10.1042/bj2000605.
9
Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine.饮食中亮氨酸过量对大鼠色氨酸代谢的影响：亮氨酸致糙皮病作用的一种机制。
Br J Nutr. 1983 Jul;50(1):25-32. doi: 10.1079/bjn19830068.
10
Effect of excess leucine on tryptophan oxygenase, 3-hydroxyanthranilate oxygenase and leucine aminotransferase in livers of young rats.过量亮氨酸对幼鼠肝脏中色氨酸加氧酶、3-羟基邻氨基苯甲酸加氧酶和亮氨酸转氨酶的影响。
Ann Nutr Metab. 1982;26(5):296-300. doi: 10.1159/000176577.
引用本文的文献
1
Machine Learning Methods Improve Specificity in Newborn Screening for Isovaleric Aciduria.机器学习方法提高了异戊酸血症新生儿筛查的特异性。
Metabolites. 2023 Feb 18;13(2):304. doi: 10.3390/metabo13020304.
2
Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B, B, B, and B.复合维生素B族的生物学特性，第1部分：维生素B1、B2、B6和B12
Nutrients. 2022 Jan 22;14(3):484. doi: 10.3390/nu14030484.
3
An Increase in Liver Polyamine Concentration Contributes to the Tryptophan-Induced Acute Stimulation of Rat Hepatic Protein Synthesis.肝多胺浓度升高有助于色氨酸诱导的大鼠肝蛋白质合成的急性刺激。
Nutrients. 2020 Sep 1;12(9):2665. doi: 10.3390/nu12092665.
4
Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion.人类犬尿氨酸途径的评估：基线时以及急性色氨酸负荷和消耗后，血浆色氨酸、犬尿氨酸代谢物及酶表达在种族和性别差异方面的比较及其临床意义
Int J Tryptophan Res. 2016 Aug 10;9:31-49. doi: 10.4137/IJTR.S38189. eCollection 2016.
5
Tryptophan metabolism, disposition and utilization in pregnancy.孕期色氨酸的代谢、分布及利用
Biosci Rep. 2015 Sep 17;35(5):e00261. doi: 10.1042/BSR20150197.
6
Standardization of formulations for the acute amino acid depletion and loading tests.急性氨基酸消耗和负荷试验制剂的标准化
J Psychopharmacol. 2015 Apr;29(4):363-71. doi: 10.1177/0269881114565141. Epub 2015 Jan 13.
7
Mechanisms of the pellagragenic effect of leucine: stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines.亮氨酸致糙皮病效应的机制：对健康人类志愿者给予支链氨基酸后对肝脏色氨酸氧化的刺激作用以及血浆游离色氨酸和总犬尿氨酸的作用
Int J Tryptophan Res. 2014 Dec 4;7:23-32. doi: 10.4137/IJTR.S18231. eCollection 2014.
8
Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems.芳香族氨基酸向分离的大鼠肝细胞中的转运。两种不同系统摄取的特性。
Biochem J. 1986 Jan 15;233(2):499-506. doi: 10.1042/bj2330499.
9
The role of haem in the regulation of rat liver tryptophan metabolism.血红素在大鼠肝脏色氨酸代谢调节中的作用。
Biochem J. 1986 Nov 15;240(1):259-63. doi: 10.1042/bj2400259.
10
Quantification of the importance of individual steps in the control of aromatic amino acid metabolism.芳香族氨基酸代谢调控中各个步骤重要性的量化
Biochem J. 1986 Mar 15;234(3):635-47. doi: 10.1042/bj2340635.
本文引用的文献
1
Effect of leucine on enzymes of the tryptophan-niacin metabolic pathway in rat liver and kidney.亮氨酸对大鼠肝、肾色氨酸-烟酰胺代谢途径中酶的影响。
Biochem J. 1973 Jun;134(2):425-30. doi: 10.1042/bj1340425.
2
Leucine and pellagra.
Lancet. 1960 Apr 30;1(7131):954-7. doi: 10.1016/s0140-6736(60)90838-2.
3
The metabolism of L-tryptophan by isolated rat liver cells. Effect of albumin binding and amino acid competition on oxidatin of tryptophan by tryptophan 2,3-dioxygenase.大鼠离体肝细胞对L-色氨酸的代谢。白蛋白结合及氨基酸竞争对色氨酸2,3-双加氧酶氧化色氨酸的影响。
Biochem J. 1980 Mar 15;186(3):977-86. doi: 10.1042/bj1860977.
4
The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism.离体大鼠肝细胞对L-色氨酸的代谢。色氨酸代谢各途径相对重要性的定量分析以及营养状况对这些途径的影响。
Biochem J. 1980 Nov 15;192(2):673-86. doi: 10.1042/bj1920673.
5
6
Binding of branched-chain 2-oxo acids to bovine serum albumin.支链2-氧代酸与牛血清白蛋白的结合。
Biochem J. 1982 Apr 15;204(1):265-72. doi: 10.1042/bj2040265.
7
A convenient and highly sensitive spectrophotometric assay for tryptophan 2,3-dioxygenase.一种用于色氨酸2,3-双加氧酶的简便且高灵敏度的分光光度测定法。
Anal Biochem. 1982 Mar 15;121(1):10-6. doi: 10.1016/0003-2697(82)90550-4.
8
Heterogeneity of Na+-independent 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid and L-leucine transport in isolated rat hepatocytes in primary culture.原代培养的分离大鼠肝细胞中不依赖钠离子的2-氨基双环-(2,2,1)-庚烷-2-羧酸和L-亮氨酸转运的异质性
Biochem Biophys Res Commun. 1982 Jan 15;104(1):307-13. doi: 10.1016/0006-291x(82)91975-1.
9
Effect of dietary excess leucine on the levels of branched chain alpha-keto acids and ketone bodies in blood and the liver of rats.
Int J Vitam Nutr Res. 1983;53(2):192-8.
Zotero 插件