Xu Zhihang, Du Jian, Jin Xingming, Tao Yehan, Lu Jie, Hu Jinwen, Lv Yanna, Xia Xiaodong, Wang Haisong
Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials, Liaoning Collaborative Innovation Center for Lignocellulosic Biorefinery, College of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China.
Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials, Liaoning Collaborative Innovation Center for Lignocellulosic Biorefinery, College of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China.
Carbohydr Polym. 2025 Mar 1;351:123091. doi: 10.1016/j.carbpol.2024.123091. Epub 2024 Nov 30.
Uncontrolled release of active agents in active packaging reduces antimicrobial efficacy, hindering the effective protection of perishable products from microbial infection. Herein, a novel defective engineering was proposed to design defective and hollow ZIF-8 structures grown on TEMPO oxidized cellulose nanofibrils (TOCNFs) and use them as fast-reacting nanocarriers for loading and controlled release curcumin (Cur) in sodium alginate (SA) active packaging systems (CZT-Cur-SA). By employing stable chelation between tannic acid (TA) and ZIF-8 zinc ions, the connections between zinc ions and imidazole ligands were severed to form a loose and hollow structure, which facilitates the rapid reaction and release of active ingredients triggered by pH changes in the microenvironment. Kinetic tests showed CZT-Cur-SA films released 65.68 % of Cur at pH 6.0 within 24 h, compared to 28.26 % at pH 7.0. These films demonstrated exhibited excellent mechanical properties, antioxidation capacity (82.59 %), reinforced moisture (0.51 × 10 g m s Pa) and satisfied antimicrobial effects on E. coli (1.69 %) and S. aureus (0.88 %). The optimized CZT-Cur-SA film extended strawberry shelf life to at least 7 days under ambient conditions. Our findings introduce a promising approach to designing responsive, biodegradable active packaging for enhanced food safety.
活性包装中活性剂的无控释放会降低抗菌效果，阻碍对易腐产品免受微生物感染的有效保护。在此，我们提出了一种新型缺陷工程，设计在TEMPO氧化纤维素纳米纤维（TOCNFs）上生长的缺陷型和中空ZIF-8结构，并将其用作快速反应的纳米载体，用于在海藻酸钠（SA）活性包装系统（CZT-Cur-SA）中负载和控释姜黄素（Cur）。通过利用单宁酸（TA）与ZIF-8锌离子之间的稳定螯合作用，切断锌离子与咪唑配体之间的连接，形成疏松的中空结构，这有利于微环境pH值变化引发的活性成分的快速反应和释放。动力学测试表明，CZT-Cur-SA薄膜在pH值为6.0时，24小时内释放了65.68%的Cur，而在pH值为7.时为28.26%。这些薄膜表现出优异的机械性能、抗氧化能力（82.59%）、增强的防潮性（0.51×10 g m s Pa），并对大肠杆菌（1.69%）和金黄色葡萄球菌（0.88%）具有令人满意的抗菌效果。优化后的CZT-Cur-SA薄膜在环境条件下将草莓的货架期延长至至少7天。我们的研究结果引入了一种有前景的方法，用于设计响应性、可生物降解的活性包装，以提高食品安全。
