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入院时心率与老年髋部骨折患者的死亡率相关:来自中国西北一家创伤中心的回顾性队列研究。

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China.

作者信息

Zhang Wei-Song, Chen Shao-Hua, Yang Zhi, Zhang Bin-Fei

机构信息

Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China

出版信息

BMJ Open. 2025 Jan 8;15(1):e093662. doi: 10.1136/bmjopen-2024-093662.

Abstract

OBJECTIVES

To evaluate the association between heart rate on admission and mortality in elderly patients with hip fractures.

DESIGN

A retrospective cohort study.

SETTING

At a trauma centre in northwestern China.

PARTICIPANTS

Elderly patients with hip fractures.

RESULTS

This cohort study included 2006 patients who met the study criteria. The mean heart rate at admission was 81.77±15.63 beats per minute. During follow-up, 189 patients died for all-cause reasons in 1 year. Age, coronary heart disease, cancer, dementia and time to operation were introduced in multivariate regression analysis. Multivariate logistic regression showed that heart rate was associated with mortality in geriatric patients with hip fracture (OR=1.01, 95% CI 1.00 to 1.02, p=0.0242). However, the linear association was unstable, and we found a nonlinear one. In the nonlinear association, the inflection point was 84 beats per minute. If below this threshold, each 1 beat per minute increase in heart rate was associated with a 4% increase in the risk of death (OR=1.04, 95% CI 1.01 to 1.06, p=0.0017). If greater than this threshold, the risk of death peaked and was not associated with the heart rate (OR=1.00, 95% CI 0.98 to 1.01, p=0.6691).

CONCLUSION

In conclusion, the heart rate was nonlinearly associated with 1-year mortality in geriatric patients with hip fractures. The low heart rate on admission was associated with low 1-year mortality. When the heart rate was over 84 beats per minute, the risk of death peaked, and there was no association with heart rate anymore.

TRIAL REGISTRATION NUMBER

This study was registered on the website of the Chinese Clinical Trial Registry (ChiCTR: ChiCTR2200057323).

摘要

目的

评估老年髋部骨折患者入院时心率与死亡率之间的关联。

设计

一项回顾性队列研究。

地点

中国西北部的一家创伤中心。

参与者

老年髋部骨折患者。

结果

这项队列研究纳入了2006名符合研究标准的患者。入院时的平均心率为每分钟81.77±15.63次。随访期间,189名患者在1年内因各种原因死亡。在多因素回归分析中纳入了年龄、冠心病、癌症、痴呆和手术时间。多因素逻辑回归显示,心率与老年髋部骨折患者的死亡率相关(OR=1.01,95%CI 1.00至1.02,p=0.0242)。然而,线性关联不稳定,我们发现了一种非线性关联。在非线性关联中,拐点为每分钟84次心跳。如果低于这个阈值,心率每增加每分钟1次,死亡风险增加4%(OR=1.04,95%CI 1.01至1.06,p=0.0017)。如果高于这个阈值,死亡风险达到峰值,且与心率无关(OR=1.00,95%CI 0.98至1.01,p=0.6691)。

结论

总之,老年髋部骨折患者的心率与1年死亡率呈非线性关联。入院时心率低与1年死亡率低相关。当心率超过每分钟84次时,死亡风险达到峰值,且与心率不再相关。

试验注册号

本研究在中国临床试验注册中心网站(ChiCTR:ChiCTR22000****)注册。 (注:原文注册号处有部分信息未完整显示,故译文此处也按原文格式体现)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1e/11748777/f461a89ec2b0/bmjopen-15-1-g001.jpg

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