Hecker Constantin, Hufnagl Clemens, Oellerer Andreas, Griessenauer Christoph J, Killer-Oberpfalzer Monika
From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria.
Department of Neurosurgery (C. Hecker, C.J.G.), Paracelsus Medical University, Salzburg, Austria.
AJNR Am J Neuroradiol. 2025 Jan 8;46(1):84-89. doi: 10.3174/ajnr.A8478.
This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.
The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.
Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.
The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.
本动物研究旨在评估新型Artisse血管内装置（ISD）用于动脉瘤栓塞的急性和短期安全性及有效性，并了解其在动脉瘤内的行为。
将该装置植入7只患有分叉动脉瘤的白色新西兰兔体内。对即刻及90天的血管造影随访以及组织学和扫描电子显微镜成像进行评估。
介入后即刻血管造影显示所有动脉瘤血流均显著减少。7个动脉瘤中有5个可见闭塞率逐渐改善。因尺寸过小导致1个装置移位，致使闭塞率相应恶化。三个月的显微镜检查显示生物相容性良好。值得注意的是，Artisse ISD显示动脉瘤腔内结缔组织形成增加，这与血管造影结果相关。
新型Artisse ISD能很好地适应动脉瘤形态，即刻造成造影剂滞留并实现良好的瘤颈覆盖。虽然血管造影结果显示3个月时仅达到中度充分闭塞，但组织学数据显示，在所有接受Artisse ISD治疗的动脉瘤中，生物相容性良好，动脉瘤腔内结缔组织形成良好。尺寸选择和正确定位对于充分闭塞似乎至关重要。
