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Stress responses induced by perturbation of the ubiquitin-proteasome system.
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Proteasome-mediated proteostasis: Novel medicinal and pharmacological strategies for diseases.
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4
Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system.
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Ubiquitin-proteasome pathway and cellular responses to oxidative stress.
Free Radic Biol Med. 2011 Jul 1;51(1):5-16. doi: 10.1016/j.freeradbiomed.2011.03.031. Epub 2011 Apr 8.
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Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis.
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Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance.
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Ubiquitin-Proteasome Pathway and Muscle Atrophy.
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Stress- and ubiquitylation-dependent phase separation of the proteasome.
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An adaptive stress response that confers cellular resilience to decreased ubiquitination.
Nat Commun. 2023 Nov 14;14(1):7348. doi: 10.1038/s41467-023-43262-7.
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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging.
Cell Metab. 2021 Jun 1;33(6):1137-1154.e9. doi: 10.1016/j.cmet.2021.03.005. Epub 2021 Mar 26.
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DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1.
Mol Cell. 2020 Jul 16;79(2):332-341.e7. doi: 10.1016/j.molcel.2020.05.035. Epub 2020 Jun 9.
4
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression.
Cell. 2019 Apr 18;177(3):737-750.e15. doi: 10.1016/j.cell.2019.03.035.
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Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
J Biol Chem. 2012 Mar 23;287(13):10021-10031. doi: 10.1074/jbc.M111.277145. Epub 2012 Feb 3.
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Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.
J Biol Chem. 2011 Oct 21;286(42):36652-66. doi: 10.1074/jbc.M111.285924. Epub 2011 Aug 30.
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Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop.
Mol Cell. 2010 Oct 8;40(1):147-58. doi: 10.1016/j.molcel.2010.09.012.
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An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.
Cell. 2009 May 1;137(3):549-59. doi: 10.1016/j.cell.2009.02.028.
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A ubiquitin stress response induces altered proteasome composition.
Cell. 2007 May 18;129(4):747-59. doi: 10.1016/j.cell.2007.03.042.

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