Rai Mamta, Hunt Liam C, Demontis Fabio
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Biology, Rhodes College, 2000 North Pkwy, Memphis, TN 38112, USA.
Trends Biochem Sci. 2025 Mar;50(3):175-178. doi: 10.1016/j.tibs.2024.12.011. Epub 2025 Jan 7.
The ubiquitin-proteasome system is key for proteostasis and its disruption can induce several cellular adaptations. Here, we summarize the range of cellular responses that are induced by perturbation of distinct components of the ubiquitin-proteasome system, and how proteasome stress in a tissue can induce systemic responses in distant tissues.
泛素-蛋白酶体系统是蛋白质稳态的关键,其破坏可诱导多种细胞适应性变化。在这里,我们总结了由泛素-蛋白酶体系统不同组分的扰动所诱导的细胞反应范围,以及组织中的蛋白酶体应激如何在远处组织中诱导全身反应。