SWI/SNF复合物在膀胱癌中的作用。

The Role of SWI/SNF Complex in Bladder Cancer.

作者信息

Lei Zixiao, Han Yanfeng, Liao Jiejun, Li Xiaohong, Su Qisheng, Yang Zheng

机构信息

Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning, Guangxi Zhuang Autonomous Region, China.

出版信息

J Cell Mol Med. 2025 Jan;29(1):e70348. doi: 10.1111/jcmm.70348.

DOI:10.1111/jcmm.70348

PMID:39779467

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11710939/

Abstract

Bladder cancer originates from bladder tissues and is the ninth most common type of cancer worldwide. The SWI/SNF (SWItch/sucrose non- fermentable) complex plays a crucial role in regulating various biological processes, such as cell cycle control, DNA damage repair and transcription regulation. The purpose of this article is to examine the functional studies of the SWI/SNF complex in bladder cancer, highlighting new pathways for creating personalised treatment approaches for bladder cancer patients with mutations in the SWI/SNF complex. By acquiring a comprehensive understanding of the mechanisms of the SWI/SNF complex in bladder cancer, we can offer more precise and effective solutions to treat this disease.

摘要

膀胱癌起源于膀胱组织，是全球第九大常见癌症类型。SWI/SNF（开关/蔗糖非发酵）复合体在调节各种生物学过程中起着关键作用，如细胞周期控制、DNA损伤修复和转录调控。本文旨在探讨SWI/SNF复合体在膀胱癌中的功能研究，重点介绍为携带SWI/SNF复合体突变的膀胱癌患者创造个性化治疗方法的新途径。通过全面了解SWI/SNF复合体在膀胱癌中的作用机制，我们可以提供更精确、有效的治疗方案来治疗这种疾病。