Dhengle Sahil, Maharana Krushna Ch, Meenakshi Sarasa, Singh Sanjiv
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Curr Pharm Des. 2025 Mar 3;31(15):1167-1179. doi: 10.2174/0113816128332969241120030733.
Monocyte chemoattractant protein-1 (MCP-1) is regarded as a crucial proinflammatory cytokine that controls the migration and entry of macrophages. It has been demonstrated that chemokine ligand 2 and its receptor, chemokine receptor 2, are both implicated in several liver disorders. In a similar context, immunity mediators are overexpressed and stimulated by MCP-1. Additionally, MCP-1 alters the physiology of the hepatocytes, promoting immunologic and inflammatory responses beyond regular metabolism. Alcoholism and other factor including abnormal diet stimulate the liver's synthesis of MCP-1, which can result in inflammation in liver. Studies shows how MCP-1' linked to various liver disorders like alcoholic liver disease, liver fibrosis, non-alcoholic fatty liver disease, hepatitis, hepatic steatosis, hepatocellular cancer, primary biliary cirrhosis. MCP-1 not only predicts the onset, progression, and prognosis of the illness, but it is also directly related to the degree and stage of liver inflammation. In this review, we will explore the mechanism and connection between MCP-1's overexpression in liver disorders, further how it can be linked as a therapeutic biomarker in the above scenario.
单核细胞趋化蛋白-1（MCP-1）被视为一种关键的促炎细胞因子，可控制巨噬细胞的迁移和进入。已有研究表明，趋化因子配体2及其受体趋化因子受体2均与多种肝脏疾病有关。在类似情况下，免疫介质会被MCP-1过度表达和刺激。此外，MCP-1会改变肝细胞的生理功能，促进超出正常代谢的免疫和炎症反应。酗酒和包括异常饮食在内的其他因素会刺激肝脏合成MCP-1，这可能导致肝脏炎症。研究表明了MCP-1如何与各种肝脏疾病相关联，如酒精性肝病、肝纤维化、非酒精性脂肪性肝病、肝炎、肝脂肪变性、肝细胞癌、原发性胆汁性肝硬化。MCP-1不仅可预测疾病的发生、发展和预后，还与肝脏炎症的程度和阶段直接相关。在本综述中，我们将探讨肝脏疾病中MCP-1过度表达之间的机制和联系，以及在上述情况下它如何作为一种治疗生物标志物。
