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通过口服米诺环素和热疗成功治疗感染。

infection successfully treated with oral administration of minocycline and thermotherapy.

作者信息

Morita Yuka, Tanahashi Kana, Terashima-Murase Chiaki, Fukaura Ryo, Oka Keisuke, Yagi Tetsuya, Miyamoto Yuji, Ato Manabu, Ishii Norihisa, Akiyama Masashi

机构信息

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Nagoya J Med Sci. 2024 Nov;86(4):699-702. doi: 10.18999/nagjms.86.4.699.

Abstract

We report a case of a woman presenting with an erythematous finger nodule, with a history of exposure to tropical fish. The erythematous nodules subsequently spread proximally from the finger. Initial treatment with oral amoxicillin-clavulanate was unsuccessful, and she developed a drug eruption. Treatment with oral minocycline and thermotherapy was initiated, as we suspected infection with () from her history and clinical features. A culture from a skin biopsy from the finger grew , confirming the diagnosis. There is no established treatment regimen for skin infections caused by . In this case, it took time for cultures to confirm the diagnosis of non-tuberculous mycobacterial infection. While it would be ideal to await culture results, we felt it was better for the patient to initiate treatment, and in infections, minocycline is considered particularly effective. However, it was envisaged that this would result in a prolonged treatment course, leading to potential resistance. Thermotherapy was added in an attempt to shorten the treatment period. This regime was successful, and the patient has remained free of recurrence since. The early initiation of treatment for cutaneous non-tuberculous mycobacterial infection requires aggressive suspicion. Also, testing, including adequate sampling and culturing, is essential for an accurate diagnosis. Slow-growing mycobacteria may take several months to be definitively diagnosed, as they grow only under certain conditions. Therefore, thorough clinical history-taking and information sharing with the microbiology team are essential. Our case illustrates this, and we believe this has important educational value.

摘要

我们报告了一例女性患者,她手指出现红斑结节,有接触热带鱼的病史。这些红斑结节随后从手指向近端扩散。最初口服阿莫西林 - 克拉维酸治疗失败,她出现了药物疹。鉴于她的病史和临床特征,我们怀疑感染了(),于是开始用口服米诺环素和热疗进行治疗。手指皮肤活检的培养物培养出了(),从而确诊。对于由()引起的皮肤感染,尚无既定的治疗方案。在这个病例中,培养结果确诊非结核分枝杆菌感染花费了一些时间。虽然等待培养结果是理想的,但我们认为对患者来说开始治疗更好,在()感染中,米诺环素被认为特别有效。然而,可以预见这会导致治疗疗程延长,引发潜在耐药性。因此添加了热疗以试图缩短治疗期。该方案取得了成功,患者自此未再复发。对于皮肤非结核分枝杆菌感染,早期开始治疗需要高度怀疑。此外,包括充分采样和培养在内的检测对于准确诊断至关重要。生长缓慢的分枝杆菌可能需要数月才能明确诊断,因为它们仅在特定条件下生长。因此,全面的临床病史采集以及与微生物学团队的信息共享至关重要。我们的病例说明了这一点,并且我们认为这具有重要的教育价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b6d/11704770/e7ac8edc737a/2186-3326-86-0699-g001.jpg

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