Yuan Qiang, Jiang Hangyu, Zhu Maofei, Chu Yueming, Zhang Yan, Bie Jun, Li Lin
Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China, 637003.
School of Pharmacy, North Sichuan Medical College, Nanchong, China, 637100.
J Cancer. 2025 Jan 1;16(3):765-783. doi: 10.7150/jca.101798. eCollection 2025.
Melanoma poses a significant challenge to patients due to its aggressive nature and limited treatment options. Recent studies have suggested that lasalocid, a feed additive ionophore antibiotic, may have potential as an anticancer agent. However, the mechanism of lasalocid in melanoma is unclear. This study found that lasalocid could inhibit melanoma cell proliferation, migration, and invasion, while inducing cell cycle arrest and apoptosis. Transcriptome sequencing and bioinformatics analysis identified FOXM1 as the hub gene of lasalocid-mediated melanoma treatment. experiments confirmed that lasalocid regulates FOXM1 expression through the PI3K/AKT and JNK/P38 MAPK pathways. experiments showed that lasalocid effectively inhibited melanoma growth with acceptable safety. In summary, our study results emphasize lasalocid's potential as a melanoma therapeutic agent and elucidate its role in regulating FOXM1 through the PI3K/AKT and JNK/P38 MAPK pathways.
黑色素瘤因其侵袭性和有限的治疗选择，给患者带来了重大挑战。最近的研究表明，饲料添加剂离子载体抗生素拉沙洛西可能具有作为抗癌剂的潜力。然而，拉沙洛西在黑色素瘤中的作用机制尚不清楚。本研究发现，拉沙洛西可抑制黑色素瘤细胞的增殖、迁移和侵袭，同时诱导细胞周期停滞和凋亡。转录组测序和生物信息学分析确定FOXM1是拉沙洛西介导的黑色素瘤治疗的关键基因。实验证实，拉沙洛西通过PI3K/AKT和JNK/P38 MAPK途径调节FOXM1的表达。实验表明，拉沙洛西在可接受的安全性下有效抑制黑色素瘤生长。总之，我们的研究结果强调了拉沙洛西作为黑色素瘤治疗剂的潜力，并阐明了其通过PI3K/AKT和JNK/P38 MAPK途径调节FOXM1的作用。
