Chuang Tzyy-Ling, Chen Pao-Liang, Koo Malcolm, Chuang Mei-Hua, Wang Yuh-Feng
Department of Nuclear Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan.
School of Medicine Tzu Chi University Hualien Taiwan.
Obes Sci Pract. 2025 Jan 8;11(1):e70037. doi: 10.1002/osp4.70037. eCollection 2025 Feb.
Osteoporosis significantly affects older adults by reducing bone mass and increasing fracture risk, thereby impacting morbidity and mortality. This study aimed to investigate the relationship between bone mineral density (BMD), body mass index (BMI), and trabecular bone score (TBS) among middle-aged and older men with or without benign prostatic hyperplasia (BPH).
A retrospective study was conducted using health examination data from male participants aged 50-98 years collected at a regional hospital in southern Taiwan. Simple and multiple linear regression analyses were employed to examine the relationships between TBS and the independent variables. A total of 3714 middle-aged and older men were included in the analysis.
Findings indicated that higher BMI was associated with greater BMD; however, the relationship with TBS suggested potential bone quality degradation in cases of underweight and obesity. Multiple linear regression analysis demonstrated that age, waist circumference, BMD, underweight status, and obesity were significantly associated with TBS.
This study revealed the associative relationship between BMI and bone health: higher BMI was associated with increased bone density but also related to a decline in bone quality as measured by TBS, particularly in cases of obesity. These results emphasized the importance of managing BMI to optimize both bone density and quality, especially in middle-aged and older men with or at risk of BPH.
骨质疏松症通过降低骨量和增加骨折风险，对老年人产生显著影响，进而影响发病率和死亡率。本研究旨在调查患有或未患有良性前列腺增生（BPH）的中老年男性的骨矿物质密度（BMD）、体重指数（BMI）和小梁骨评分（TBS）之间的关系。
利用台湾南部一家地区医院收集的50 - 98岁男性参与者的健康检查数据进行回顾性研究。采用简单和多元线性回归分析来检验TBS与自变量之间的关系。共有3714名中老年男性纳入分析。
研究结果表明，较高的BMI与较高的BMD相关；然而，与TBS的关系表明，体重过轻和肥胖情况下可能存在骨质退化。多元线性回归分析表明，年龄、腰围、BMD、体重过轻状态和肥胖与TBS显著相关。
本研究揭示了BMI与骨骼健康之间的关联关系：较高的BMI与骨密度增加相关，但也与TBS所衡量的骨质下降有关，尤其是在肥胖情况下。这些结果强调了控制BMI以优化骨密度和骨质的重要性，特别是对于患有或有BPH风险的中老年男性。
