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计算机化认知训练对亨廷顿舞蹈症的影响及机制：一项试点研究方案

Effects and mechanisms of computerized cognitive training in Huntington's disease: protocol for a pilot study.

作者信息

Huynh Katharine, Jamadar Sharna, Stout Julie, Voigt Katharina, Lampit Amit, Georgiou-Karistianis Nellie

机构信息

Turner Institute for Brain & Mental Health, School of Psychological Sciences, Faculty of Medicine, Nursing & Health Sciences, 18 Innovation Walk, Monash University, Clayton VIC 3800, Australia.

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Grattan St, Parkville VIC 3010, Australia.

出版信息

Neurodegener Dis Manag. 2024;14(6):203-216. doi: 10.2217/nmt-2023-0001. Epub 2024 May 11.

DOI:10.2217/nmt-2023-0001
PMID:39781626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11730119/
Abstract

Huntington's disease (HD) causes progressive cognitive decline, with no available treatments. Computerized cognitive training (CCT) has shown efficacy in other populations, but its effects in HD are largely unknown. This pilot study will explore the effects and neural mechanisms of CCT in HD. The intervention group participants will complete 12 weeks of multidomain CCT. Control group participants will receive lifestyle education and access to CCT after the study. The primary outcome is change in processing speed. Secondary outcomes include - change in other cognitive domains, functional brain network connectivity (derived from MRI) and psychosocial function. Feasibility outcomes include rates of recruitment, adherence and retention. This study may provide insights into the effects of CCT in HD and guide future trials. ACTRN12622000908730 (ClinicalTrials.gov).

摘要

亨廷顿舞蹈症（HD）会导致进行性认知衰退，目前尚无有效治疗方法。计算机化认知训练（CCT）在其他人群中已显示出疗效，但其对HD患者的影响在很大程度上尚不清楚。这项初步研究将探讨CCT对HD患者的影响及其神经机制。干预组参与者将完成为期12周的多领域CCT。对照组参与者将接受生活方式教育，并在研究结束后可使用CCT。主要结局是处理速度的变化。次要结局包括其他认知领域的变化、功能性脑网络连通性（源自MRI）和心理社会功能。可行性结局包括招募率、依从性和保留率。本研究可能为CCT对HD患者的影响提供见解，并指导未来的试验。ACTRN12622000908730（ClinicalTrials.gov）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/dbf7f459cdb3/INMT_A_2340276_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/de69e90c53aa/INMT_A_2340276_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/9d8254db52b4/INMT_A_2340276_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/dbf7f459cdb3/INMT_A_2340276_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/de69e90c53aa/INMT_A_2340276_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/9d8254db52b4/INMT_A_2340276_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d5/11730119/dbf7f459cdb3/INMT_A_2340276_F0003_C.jpg

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