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黄芩素在神经系统疾病中的治疗作用

Therapeutic Role of Scutellarein in Neurological Disorders.

作者信息

Kumar Rohit, Bai Sucharitha, Shukla Rahul, Naqvi Saba

机构信息

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Lucknow (UP) 226002, India.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Lucknow (UP) 226002, India.

出版信息

Curr Pharm Des. 2025;31(20):1583-1592. doi: 10.2174/0113816128336901241125092132.

Abstract

Scutellarein, a flavone found in the perennial herb Scutellaria baicalensis, has a wide range of pharmacological actions, such as antioxidant, anti-inflammatory, and neuroprotective. Increasing evidence has emphasized the developing significance of scutellarein in several neurological illnesses, such as Alzheimer's and Parkinson's disease, cerebral ischemia, and neuroblastoma. This review is centered on the molecular processes that underlie the neuroprotective properties of scutellarein in various neurological disorders, as indicated by recent pre-clinical research. Furthermore, it critically examines the potential challenges and advantages of scutellarein inclusion within the range of treatments for neurological disorders.

摘要

黄芩素是一种存在于多年生草本植物黄芩中的黄酮类化合物,具有广泛的药理作用,如抗氧化、抗炎和神经保护作用。越来越多的证据强调了黄芩素在几种神经系统疾病中的发展意义,如阿尔茨海默病、帕金森病、脑缺血和神经母细胞瘤。正如最近的临床前研究所表明的,本综述聚焦于黄芩素在各种神经系统疾病中发挥神经保护作用的分子机制。此外,它还批判性地审视了将黄芩素纳入神经系统疾病治疗范围内的潜在挑战和优势。

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