[肝脏酶系统对脂肪族醇类的氧化机制]
[Mechanisms of aliphatic alcohols oxidation by enzymatic systems of the liver].
作者信息
Metelitsa D I, Popova E M
出版信息
Biokhimiia. 1979 Nov;44(11):1923-35.
PMID:397836
Abstract
The main pathways of aliphatic alcohols oxidation in human and mammalian liver, i.e. dehydration of alcohols by cytosolic alcohol dehydrogenases and oxidation in the presence of microsomal enzymatic system, catalase and hydrogen peroxide are described. A special emphasis is laid upon the interaction of alcohols with terminal oxidase of the microsomal hydroxylating system, i.e. cytochrome P-450. The relative role of these three oxidative pathways in alcohol conversions is evaluated.
摘要
描述了人类和哺乳动物肝脏中脂肪醇氧化的主要途径，即胞质醇脱氢酶使醇脱水以及在微粒体酶系统、过氧化氢酶和过氧化氢存在下的氧化。特别强调了醇与微粒体羟化系统的末端氧化酶即细胞色素P - 450的相互作用。评估了这三种氧化途径在醇转化中的相对作用。
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