Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal.
作者信息
Fernández-Sanromán Ángel, Fendler Annika, Tan Benjy J Y, Cattin Anne-Laure, Spencer Charlotte, Thompson Rachael, Au Lewis, Lobon Irene, Pallikonda Husayn Ahmed, Martin Alice, Byrne Fiona, Franz Antonia, Mikolajczak Anna, Rahman Haseeb, Tippu Zayd, Shepherd Scott T C, Feng Hugang, Deng Daqi, Rowan Andrew, Pickering Lisa, Furness Andrew J S, Young Kate, Nicol David, Rudman Sarah Maria, O'Brien Tim, Edmonds Kim, Chandra Ashish, Hazell Steve, Litchfield Kevin, Kassiotis George, Larkin James, Turajlic Samra
机构信息
Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Spanish National Cancer Research Center (CNIO), Madrid, Spain.
出版信息
Cancer Discov. 2025 Jan 9:OF1-OF23. doi: 10.1158/2159-8290.CD-24-0499.
Using joint genomic-transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, potential cGAS-STING repression, and increased cell proliferation. These patterns can aid clinical management and guide novel treatment approaches.
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