Martin L J, Doebler J A, Shih T M, Anthony A
Brain Res. 1985 Jan 28;325(1-2):287-9. doi: 10.1016/0006-8993(85)90324-5.
Histopathological analyses of brains of rats receiving a single 0.9 LD50 injection of soman, a potent anticholinesterase neurotoxin, revealed massive widespread lesions in the cerebral cortex and thalamus 4 weeks post-injection. Such lesions were not evidenced in rats receiving diazepam (2.2 mg/kg, i.m.) 10 min prior to soman treatment. Thus, anticonvulsant antidotes may aid in preventing extensive or permanent brain damage in rats surviving near-lethal soman dosages.
对接受单次0.9倍半数致死剂量梭曼（一种强效抗胆碱酯酶神经毒素）注射的大鼠脑部进行组织病理学分析，结果显示在注射后4周，大脑皮层和丘脑出现大量广泛的损伤。在梭曼治疗前10分钟接受地西泮（2.2毫克/千克，肌肉注射）的大鼠中未发现此类损伤。因此，抗惊厥解毒剂可能有助于预防在接近致死剂量梭曼中毒后存活的大鼠出现广泛或永久性脑损伤。
