de Castro Mendes Francisca, Severo Milton, Paciência Inês, Lopes Carla, Santos Ana Cristina, Barros Henrique, Moreira André, Moreira Pedro
EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.
Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
Pediatr Allergy Immunol. 2025 Jan;36(1):e70024. doi: 10.1111/pai.70024.
We aimed to investigate the association between maternal caffeine intake during pregnancy and asthma in children by 10 years of age.
We considered 5585 mother-child pairs enrolled in a population-based birth cohort. Consumption of regular and decaffeinated coffee, black and green tea, and cola beverages before and during pregnancy was obtained through face-to-face interviews within 72 h after giving birth, and total caffeine intake (mg/day) was estimated. Medical diagnosis of asthma was assessed and spirometry with bronchodilation was performed at 10 years of age. We used adjusted regression models to estimate the association between the caffeine intake/day during pregnancy with asthma by 10 years of age, and a quadratic relationship was verified between them. Consumption of caffeine before pregnancy, gestational age, maternal years of schooling, maternal self-reported medical diagnosis of asthma, smoking status before and during pregnancy, and children's sex were considered as confounders. We used nonlinear least squares models to estimate the knot point and its respective confidence interval (CI).
A higher intake of caffeine/day decreased the odds of having childhood asthma at 10 years of age (adjusted odds ratio [OR] = 0.60, 95% CI: 0.41; 0.88). The estimated knot point was 92.7 mg of caffeine/day (95% CI: 36.3, 163.3), where the risk was 7.2%, while for no intake (0 mg) the risk was 8.8%.
Maternal caffeine intake up to an estimated intake of approximately 93 mg/day during pregnancy decreased childhood asthma risk by 10 years of age. Nonetheless, further studies are required to confirm our results.
Maternal caffeine intake during pregnancy up to an estimated intake of approximately 93 mg/day decreased the risk of asthma in children by 10 years of age, but considering caffeine's potential adverse effects on other health outcomes, further studies are needed to explore its link to childhood asthma.
我们旨在研究孕期母亲咖啡因摄入量与10岁儿童哮喘之间的关联。
我们纳入了5585对参与基于人群的出生队列研究的母婴对。通过产后72小时内的面对面访谈获取孕期及孕前常规咖啡、脱咖啡因咖啡、红茶、绿茶和可乐饮料的消费量，并估算每日咖啡因总摄入量（毫克/天）。在儿童10岁时评估哮喘的医学诊断并进行支气管扩张后的肺功能测定。我们使用校正回归模型估算孕期每日咖啡因摄入量与10岁时哮喘之间的关联，并验证了二者之间的二次关系。孕前咖啡因摄入量、孕周、母亲受教育年限、母亲自我报告的哮喘医学诊断、孕期及孕前吸烟状况以及儿童性别被视为混杂因素。我们使用非线性最小二乘法模型估算节点及其各自的置信区间（CI）。
每日咖啡因摄入量较高会降低10岁儿童患哮喘的几率（校正比值比[OR] = 0.60，95% CI：0.41；0.88）。估算的节点为每日92.7毫克咖啡因（95% CI：36.3，163.3），此时风险为7.2%，而无咖啡因摄入（0毫克）时风险为8.8%。
孕期母亲咖啡因摄入量估计达约93毫克/天可降低10岁儿童患哮喘的风险。尽管如此，仍需进一步研究来证实我们的结果。
孕期母亲咖啡因摄入量估计达约93毫克/天可降低10岁儿童患哮喘的风险，但考虑到咖啡因对其他健康结局的潜在不良影响，需要进一步研究来探索其与儿童哮喘的关联。
