口服地西泮负荷剂量预防酒精戒断性癫痫发作。
Prevention of alcohol withdrawal seizures with oral diazepam loading.
作者信息
Devenyi P, Harrison M L
出版信息
Can Med Assoc J. 1985 Apr 1;132(7):798-800.
Abstract
Twenty patients withdrawing from alcohol who had reliable histories of previous alcohol-withdrawal seizures and thus were at high risk for a subsequent seizure were treated in hospital with oral diazepam loading: 20 mg of the drug was given every hour to a minimum total of 60 mg. None of the patients had a seizure during the stay in hospital. We believe that phenytoin prophylaxis is not necessary in these circumstances. However, if the patient is already taking phenytoin, this drug should not be abruptly discontinued in the withdrawal period in favour of diazepam loading.
摘要
20名正在戒酒的患者，他们有可靠的既往酒精戒断性癫痫发作史，因此再次发作癫痫的风险很高，在医院接受了口服地西泮负荷治疗：每小时给予20毫克药物，最低总量为60毫克。住院期间没有患者发生癫痫发作。我们认为在这些情况下不需要预防性使用苯妥英钠。然而，如果患者已经在服用苯妥英钠，在戒断期不应突然停用该药而改用苯二氮䓬类药物负荷治疗。
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