Vernon S W, Tilley B C, Neale A V, Steinfeldt L
Cancer. 1985 Apr 1;55(7):1563-71. doi: 10.1002/1097-0142(19850401)55:7<1563::aid-cncr2820550726>3.0.co;2-1.
This study examined differences in 10-year survival rates from breast cancer among white, black, and Hispanic women controlling for the effects of age, socioeconomic status (SES), stage of disease, and delay in seeking treatment for symptoms. Breast cancer patients (n = 1983) treated at M. D. Anderson Hospital and Tumor Institute in Houston, Texas between 1949 and 1968, were followed for 10 years. Ethnicity, SES, stage of disease, and delay were all found to affect survival when considered separately. Black patients were less likely to survive than either white or Hispanic patients whose survival experience appeared to be similar. Multivariate analysis that used a Cox regression technique showed that ethnic differences remained when age, SES, stage, and delay were included in the model. In contrast, the authors could not detect an effect of delay on survival when ethnicity and all other variables were included. These data suggest that ethnic differences in breast cancer survival are not mediated by differences in delay in seeking treatment for breast cancer symptoms.
本研究调查了白人、黑人及西班牙裔女性乳腺癌患者的10年生存率差异，同时控制了年龄、社会经济地位（SES）、疾病分期以及症状出现至寻求治疗的延迟时间等因素的影响。对1949年至1968年间在得克萨斯州休斯敦市MD安德森医院和肿瘤研究所接受治疗的1983例乳腺癌患者进行了为期10年的随访。单独考虑时，种族、SES、疾病分期和延迟时间均被发现会影响生存率。黑人患者的生存率低于白人或西班牙裔患者，而后两者的生存情况似乎相似。使用Cox回归技术的多变量分析表明，当模型纳入年龄、SES、分期和延迟时间时，种族差异仍然存在。相反，当纳入种族及所有其他变量时，作者未发现延迟时间对生存率有影响。这些数据表明，乳腺癌生存方面的种族差异并非由乳腺癌症状出现至寻求治疗的延迟时间差异所介导。
