Kyriakos M, Land V J, Penning H L, Parker S G
Cancer. 1985 Apr 15;55(8):1770-89. doi: 10.1002/1097-0142(19850415)55:8<1770::aid-cncr2820550825>3.0.co;2-q.
A boy with metastatic and fatal chondroblastoma is presented. Unlike previously published examples of metastatic chondroblastoma, these metastases developed before any operative manipulation of the primary tumor. The histologic characteristics of the primary, metastatic, and locally recurrent tumors were those of a conventional chondroblastoma. A review of published cases of atypical, aggressive, and malignant chondroblastoma is presented with current follow-up information. Although some metastatic chondroblastomas may result from operative manipulation of the primary tumor and are clinically benign, other histologically benign chondroblastomas exist that are capable of pursuing a malignant course. The authors designate these as malignant chondroblastomas. No histologic criteria exist for the separation of these tumors.
本文报告了一名患有转移性致命性软骨母细胞瘤的男孩。与先前发表的转移性软骨母细胞瘤病例不同，这些转移灶在对原发肿瘤进行任何手术操作之前就已出现。原发肿瘤、转移瘤和局部复发性肿瘤的组织学特征均为典型的软骨母细胞瘤。本文结合当前的随访信息，对已发表的非典型、侵袭性和恶性软骨母细胞瘤病例进行了综述。尽管一些转移性软骨母细胞瘤可能是由于对原发肿瘤的手术操作引起的，且临床上为良性，但也存在其他组织学上为良性的软骨母细胞瘤，它们可能会发展为恶性病程。作者将这些肿瘤称为恶性软骨母细胞瘤。目前尚无区分这些肿瘤的组织学标准。
