Lipson A, Bale P
Cancer. 1985 May 1;55(9):1859-62. doi: 10.1002/1097-0142(19850501)55:9<1859::aid-cncr2820550902>3.0.co;2-f.
Ependymoblastoma developed in a 28-month-old girl whose epileptic mother took diphenylhydantoin and methylphenobarbitone throughout pregnancy. The child was also shown to be a genetic carrier for ornithine transcarbamylase deficiency, an x-linked inborn error of urea cycle metabolism. The possibility of transplacental carcinogenesis should be considered, as other juvenile embryonic tumors such as neuroblastoma, melanotic neuroectodermal tumor, and mesenchymoma have been reported in offspring after diphenylhydantoin use by the mother during pregnancy.
一名28个月大的女孩患上了室管膜母细胞瘤，其患有癫痫的母亲在整个孕期都服用苯妥英钠和甲基苯巴比妥。该患儿还被证明是鸟氨酸转氨甲酰酶缺乏症的基因携带者，这是一种X连锁的尿素循环代谢先天性缺陷。应考虑经胎盘致癌的可能性，因为有报道称，母亲在孕期使用苯妥英钠后，其后代出现了其他青少年胚胎性肿瘤，如神经母细胞瘤、黑色素性神经外胚层肿瘤和间叶瘤。
