Thomson A B, Rennie P S, Walker K, Cheeseman C
Cancer Res. 1985 Apr;45(4):1479-82.
An in vitro technique was used to examine the rate of uptake of varying concentrations of glucose, galactose, and a homologous series of saturated fatty acids into the jejunum of control rats and Noble rats bearing prostatic tumor variants of primary human prostatic adenocarcinoma 52. Both groups of animals were healthy, eating and gaining weight normally. The uptake of acetic and butyric acid was reduced in tumor-bearing rats, but the uptake of four medium chain-length fatty acids was unchanged. The similar value of the incremental change in free energy in the control and tumor-bearing animals indicates similar passive permeability properties of the jejunum in the two groups. The uptake of varying concentrations of glucose and galactose was similar in the control and in the tumor-bearing animals. It is concluded that there are only subtle changes in nutrient uptake in tumor-bearing rats that are eating and gaining weight normally. It is suggested that any alteration in nutrient absorption which might occur in the cachectic tumor-bearing animal is probably due to alterations in food intake or body weight, rather than due to a direct effect of the tumor on the intestine.
采用体外技术检测对照大鼠以及携带原发性人前列腺腺癌52前列腺肿瘤变体的诺布尔大鼠空肠对不同浓度葡萄糖、半乳糖和一系列饱和脂肪酸同系物的摄取速率。两组动物均健康，正常饮食且体重增加。荷瘤大鼠对乙酸和丁酸的摄取减少，但对四种中链长度脂肪酸的摄取未变。对照动物和荷瘤动物中自由能增量变化的相似值表明两组空肠的被动通透性特性相似。对照动物和荷瘤动物对不同浓度葡萄糖和半乳糖的摄取相似。得出的结论是，正常饮食且体重增加的荷瘤大鼠在营养物质摄取方面仅有细微变化。有人提出，恶病质荷瘤动物可能出现的营养吸收改变可能是由于食物摄入量或体重的改变，而非肿瘤对肠道的直接影响。
