短期过度喂养对小鼠能量平衡的时间分辨效应
Time-Resolved Effects of Short-term Overfeeding on Energy Balance in Mice.
作者信息
Ranea-Robles Pablo, Lund Camilla, Svendsen Charlotte, Gil Cláudia, Lund Jens, Kleinert Maximilian, Clemmensen Christoffer
机构信息
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.
出版信息
Diabetes. 2025 Apr 1;74(4):502-513. doi: 10.2337/db24-0289.
Intragastric overfeeding reveals insights into the homeostatic recovery from experimental weight gain. Protection against short-term, overfeeding-induced weight gain primarily involves a profound reduction in food intake and possibly an adaptive increase in energy expenditure. UCP1-mediated thermogenesis is not essential for homeostatic protection against short-term, overfeeding-induced weight gain.
胃内过度喂养揭示了从实验性体重增加中进行稳态恢复的见解。防止短期过度喂养引起的体重增加主要涉及食物摄入量的大幅减少，以及可能的能量消耗适应性增加。UCP1介导的产热对于防止短期过度喂养引起的体重增加的稳态保护并非必不可少。
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