Wang Peng-Yu, Zuo Liao-Liao, Wu Jie-Du, Li Chao-Yu, Li Jian-Feng
Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Apr 5;330:125664. doi: 10.1016/j.saa.2024.125664. Epub 2024 Dec 25.
Since 1997, driven by advancements in nanoscience, single-molecule plasmon-enhanced Raman spectroscopy (SM-PERS) has developed into a powerful technique for ultrasensitive trace analysis through fingerprint vibrational chemical information. The nanocavity between the coupled plasmonic nanostructures, offering an exceptionally high Raman signal enhancement factor (i.e., plasmonic field hotspot), is crucial for the achievement of SM-PERS. Herein, we first briefly review the development of SM-PERS, followed by an introduction of the features and methodologies of SM-PERS, as well as the applications of SM-PERS in biological analysis, high-resolution chemical imaging, and the investigations of single-molecule reactions. Finally, a perspective highlighting the advancement of new methods and applications of nano-driven SM-PERS is presented.
自1997年以来，在纳米科学进步的推动下，单分子等离子体增强拉曼光谱（SM-PERS）已发展成为一种通过指纹振动化学信息进行超灵敏痕量分析的强大技术。耦合等离子体纳米结构之间的纳米腔提供了极高的拉曼信号增强因子（即等离子体场热点），这对于实现SM-PERS至关重要。在此，我们首先简要回顾SM-PERS的发展历程，接着介绍SM-PERS的特点和方法，以及SM-PERS在生物分析、高分辨率化学成像和单分子反应研究中的应用。最后，展望了纳米驱动的SM-PERS新方法和应用的进展。
