Nasrawi Rose, Mautner-Rohde Mika, van Ede Freek
Institute for Brain and Behavior Amsterdam, Department of Experimental and Applied Psychology, Vrije Universiteit Amsterdam, the Netherlands.
Institute for Brain and Behavior Amsterdam, Department of Experimental and Applied Psychology, Vrije Universiteit Amsterdam, the Netherlands.
Prog Neurobiol. 2025 Feb;245:102717. doi: 10.1016/j.pneurobio.2025.102717. Epub 2025 Jan 7.
It is well established that when we hold more content in working memory, we are slower to act upon part of that content when it becomes relevant for behavior. Here, we asked whether this load-related slowing is due to slower access to the sensory representations held in working memory (as predicted by serial working-memory search), or by a reduced preparedness to act upon those sensory representations once accessed. To address this, we designed a visual-motor working-memory task in which participants memorized the orientation of two or four colored bars, of which one was cued for reproduction. We independently tracked EEG markers associated with the selection of visual (cued item location) and motor (relevant manual action) information from the EEG time-frequency signal, and compared their latencies as a function of memory load. We confirm slower memory-guided behavior with higher working-memory load and show that this is associated with delayed motor selection. In contrast, we find no evidence for a concomitant delay in the latency of visual selection. Moreover, we show that variability in decision times within each memory-load condition is associated with corresponding changes in the latency of motor, but not visual selection. These results reveal how memory load affects our preparedness to act on sensory representations in working memory, while leaving sensory access itself unaffected. This posits action readiness as a key factor that shapes the speed of memory-guided behavior and that underlies delayed responding with higher working-memory load.
众所周知,当我们在工作记忆中持有更多内容时,当其中一部分内容与行为相关时,我们对其采取行动的速度会变慢。在此,我们探讨这种与负荷相关的反应迟缓是由于对工作记忆中保存的感觉表征的访问速度变慢(如串行工作记忆搜索所预测的那样),还是由于一旦访问这些感觉表征后对其采取行动的准备性降低。为了解决这个问题,我们设计了一个视觉运动工作记忆任务,参与者在其中记住两个或四个彩色条的方向,其中一个被提示进行再现。我们从脑电图时频信号中独立追踪与视觉(提示项目位置)和运动(相关手动动作)信息选择相关的脑电图标记,并比较它们作为记忆负荷函数的潜伏期。我们证实,工作记忆负荷越高,记忆引导行为越慢,并表明这与运动选择延迟有关。相比之下,我们没有发现视觉选择潜伏期同时延迟的证据。此外,我们表明,在每个记忆负荷条件下,决策时间的变异性与运动而非视觉选择潜伏期的相应变化相关。这些结果揭示了记忆负荷如何影响我们对工作记忆中感觉表征采取行动的准备性,同时不影响感觉访问本身。这将行动准备性设定为塑造记忆引导行为速度的关键因素,也是工作记忆负荷较高时反应延迟的基础。