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脂肪营养不良患者的IV型高脂蛋白血症

Type IV hyperlipoproteinemia in patients with algodystrophy.

作者信息

Guenee B, Tallet F, Raichvarg D, Ekindjian O G, Kharrat A, de Gery A, Amor B

出版信息

Clin Exp Rheumatol. 1985 Jan-Mar;3(1):49-52.

PMID:3978893
Abstract

The present work studies lipid metabolism in patients with algodystrophy (AD). A correct positive correlation (r = 0.75) between the triglyceride levels and low density lipoprotein (LDL)/very low density lipoprotein (VLDL) ratio and the VLDL increase observed by gel disk electrophoresis confirm that a type IV hyperlipoproteinemia is associated with AD. In contrast, the degree of high density lipoprotein (HDL) saturation in cholesterol (HDL-cholesterol/HDL-phospholipids) and the classical atherogenous index (cholesterol/HDL-cholesterol) were not modified. The decrease of plasma post-heparin lipolytic activities (PHLA) was not significant but further studies should be performed to correlate PHLA with a reduced activity of the adipose tissue lipoprotein lipase.

摘要

本研究探讨了脂肪营养不良(AD)患者的脂质代谢情况。甘油三酯水平与低密度脂蛋白(LDL)/极低密度脂蛋白(VLDL)比值之间存在显著正相关(r = 0.75),且通过凝胶圆盘电泳观察到VLDL升高,这证实了IV型高脂蛋白血症与AD相关。相比之下,高密度脂蛋白(HDL)中胆固醇的饱和度(HDL-胆固醇/HDL-磷脂)以及经典的动脉粥样硬化指数(胆固醇/HDL-胆固醇)并未改变。血浆肝素后脂解活性(PHLA)的降低并不显著,但应进一步开展研究,以关联PHLA与脂肪组织脂蛋白脂肪酶活性降低之间的关系。

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