Bohren Y, Cachemaille M, Timbolschi I D, Perruchoud C
Centre d'Evaluation et Traitement de la Douleur, Hôpitaux Civils de Colmar, Colmar, France.
Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France.
Cardiovasc Intervent Radiol. 2025 Jan 9. doi: 10.1007/s00270-024-03920-9.
Pain associated with cancer is often the first symptom reported with major repercussions on patient's quality of life. Mechanical compression, release of algogenic substances by the tumor or the complications of oncologic treatment represent the major causes. Nociceptive and neuropathic pain are both induced by different mediators that give rise to a neuroinflammation creating a peripheral and central sensitization responsible of chronic pain. Understanding the pain pathway may orientate to the most appropriate treatment. Oral medication should be often reevaluated to consider multimodal analgesia including interventional pain procedures with intrathecal therapy and neuromodulation.
与癌症相关的疼痛通常是患者报告的首个症状，对患者的生活质量有重大影响。机械性压迫、肿瘤释放致痛物质或肿瘤治疗并发症是主要原因。伤害性疼痛和神经性疼痛均由不同介质诱发，这些介质引发神经炎症，导致外周和中枢敏化，进而引起慢性疼痛。了解疼痛传导途径有助于确定最恰当的治疗方法。应经常重新评估口服药物，以考虑采用多模式镇痛，包括鞘内治疗和神经调节等介入性疼痛治疗方法。
