Opuchlik Katarzyna, Pankiewicz Katarzyna, Pierzyński Piotr, Sierdziński Janusz, Aleksejeva Elina, Salumets Andres, Issat Tadeusz, Laudański Piotr
Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, Warsaw, 01-211, Poland.
OVIklinika Infertility Center, Połczyńska 31, Warsaw, 01-377, Poland.
BMC Womens Health. 2025 Jan 9;25(1):15. doi: 10.1186/s12905-024-03531-z.
Embryo implantation involves two key elements: a good quality embryo and receptive endometrium. Endometrial receptivity abnormalities are known as one of the possible causes of recurrent implantation failure (RIF), especially when the embryo is euploid. This study was aimed to evaluate the impact of age and other clinical factors on endometrial receptivity in women with RIF.
68 women with RIF (defined as at least three unsuccessful transfers of good quality embryo of at least 1BB category of blastocysts) and 49 controls (women undergoing IVF treatment because of idiopathic infertility or male factor) were included to the study. After preparation of the endometrium by the hormone replacement therapy endometrial biopsies were taken from each patient and sequenced with beREADY test TAC targeting 67 biomarker genes for endometrial receptivity. Depending on the test result patients were classified into one of four different groups: pre-receptive (n = 16), early-receptive (n = 54), receptive (n = 44) and late-receptive (n = 3).
In women with RIF pre-receptive endometrium has been detected substantially more often than in controls - 13 (19,1%) vs. 3 (6,1%) patients (p = 0,043). Early-receptive endometrium was diagnosed in the majority of patients with idiopathic infertility - 12 (66.7%) vs. 6 (33.3%) women (p = 0.042) and with polycystic ovary syndrome (PCOS) - 12 (70,6%) vs. 3 (17.7%) women (p = 0,0447). We found significant association between abnormal endometrial receptivity and patient's age and duration of infertility. Young women were diagnosed significantly more often as normal or late-receptive, whereas older women with longer history of infertility as early-receptive and pre-receptive.
In patients with RIF in comparison to other women undergoing IVF procedures, patient's age and infertility duration are the most important factors related to endometrial receptivity abnormalities, indicating that older women with a longer history of infertility may benefit the most from endometrial receptivity testing.
Not applicable.
胚胎着床涉及两个关键因素：优质胚胎和容受性子宫内膜。子宫内膜容受性异常是反复着床失败（RIF）的可能原因之一，尤其是当胚胎为整倍体时。本研究旨在评估年龄和其他临床因素对RIF女性子宫内膜容受性的影响。
68例RIF女性（定义为至少三次移植至少1BB级囊胚的优质胚胎均未成功）和49例对照（因特发性不孕或男性因素接受体外受精治疗的女性）纳入研究。在通过激素替代疗法准备好子宫内膜后，从每位患者身上取子宫内膜活检组织，并使用针对67个子宫内膜容受性生物标志物基因的beREADY测试TAC进行测序。根据测试结果，患者被分为四个不同组之一：接受前期（n = 16）、早期接受期（n = 54）、接受期（n = 44）和晚期接受期（n = 3）。
与对照组相比，RIF女性中检测到接受前期子宫内膜的频率明显更高——13例（19.1%）对3例（6.1%）患者（p = 0.043）。大多数特发性不孕患者被诊断为早期接受期子宫内膜——12例（66.7%）对6例（33.3%）女性（p = 0.042），多囊卵巢综合征（PCOS）患者也是如此——12例（70.6%）对3例（17.7%）女性（p = 0.0447）。我们发现子宫内膜容受性异常与患者年龄和不孕持续时间之间存在显著关联。年轻女性被诊断为正常或晚期接受期的频率明显更高，而不孕病史较长的老年女性则被诊断为早期接受期和接受前期。
与其他接受体外受精程序的女性相比，RIF患者中，患者年龄和不孕持续时间是与子宫内膜容受性异常相关的最重要因素，这表明不孕病史较长的老年女性可能从子宫内膜容受性检测中获益最大。
不适用。
