Zhang Jiahui, Zhang Le, Wu Wenyan, Zheng Xiaowei
Department of Neonatology, Affliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, 214023, China.
Department of Neonatology, Affliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, 214023, Jiangsu, China.
BMC Public Health. 2025 Jan 9;25(1):109. doi: 10.1186/s12889-025-21316-3.
Previous studies had reported the association between famine exposure in early life and subsequent non-communicable diseases risk. In current study, we aimed to evaluate the associations between famine exposure on multimorbidity prevalence and incidence in middle-aged and older Chinese population.
A total of 13,254 participants from the China Health and Retirement Longitudinal Study 2011 were included in cross-sectional analyses. 5,780 participants were including in longitudinal analyses and were followed up in 2020. Based on the questionnaire, participants were divided into non-exposed, mild famine, moderate famine and severe famine subgroups.
In cross-sectional analyses, both mild, moderate and severe famine groups were significantly associated with higher multimorbidity prevalence. During the 9 years of follow-up, a total of 2,643(45.73%) participants with multimorbidity incident were identified. After adjusting for all covariates, individuals who experienced mild famine, moderate famine and severe famine were significantly associated with increased risk of multimorbidity incident, with the corresponding ORs (95%CI) being 1.32(1.14-1.52), 1.54(1.21-1.96) and 1.62(1.32-1.99), respectively.
Our findings indicate that famine exposure in mild, moderate and severe famine groups might be associated with an increased multimorbidity risk.
既往研究报道了早年饥荒暴露与随后患非传染性疾病风险之间的关联。在本研究中，我们旨在评估饥荒暴露与中国中老年人群中多种疾病共病的患病率和发病率之间的关联。
来自2011年中国健康与养老追踪调查的13254名参与者被纳入横断面分析。5780名参与者被纳入纵向分析，并于2020年进行随访。根据问卷，参与者被分为未暴露组、轻度饥荒组、中度饥荒组和重度饥荒组。
在横断面分析中，轻度、中度和重度饥荒组均与较高的多种疾病共病患病率显著相关。在9年的随访期间，共识别出2643名（45.73%）发生多种疾病共病的参与者。在调整所有协变量后，经历轻度饥荒、中度饥荒和重度饥荒的个体与多种疾病共病发生风险增加显著相关，相应的比值比（95%置信区间）分别为1.32（1.14 - 至1.52）、1.54（1.21 - 1.96）和1.62（1.32 - 1.99）。
我们的研究结果表明，轻度、中度和重度饥荒组的饥荒暴露可能与多种疾病共病风险增加有关。
