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基于国家住院样本数据库(2010 - 2019年)对全肩关节置换术后肺部并发症的发生率、潜在危险因素及医学意义进行回顾性分析。

Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient Sample database (2010-2019).

作者信息

Dong Mengning, Liang Huitong, Fu Jinlang, Guo Zeying, Xie Hao, Yang Qinfeng, Yu Qingmei, Hou Xiaomin

机构信息

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.

The First Clinical Medical School, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.

出版信息

Perioper Med (Lond). 2025 Jan 10;14(1):4. doi: 10.1186/s13741-024-00490-9.

DOI:10.1186/s13741-024-00490-9
PMID:39789634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11720511/
Abstract

BACKGROUND

In USA, total shoulder arthroplasty (TSA) ranks amongst the top five surgeries that require hospitalization. As a result, the healthcare system in USA could face a considerable financial strain due to the emergence of subsequent pulmonary problems. This study aimed to conduct a thorough examination of the prevalence, influential factors and medical importance of pulmonary complications, with emphasis on pneumonia, respiratory failure and pulmonary embolism (PE) following total shoulder arthroplasty (TSA) procedures in USA.

METHODS

The National Inpatient Sample (NIS) was utilized to survey all patients who underwent primary elective TSA from 2010 to 2019. Pneumonia, respiratory failure and PE following TSA were considered to be pulmonary consequences. The inpatient expenses, length of hospitalization, death rates and patient characteristics of those with and without reported perioperative pulmonary problems were compared. The utilization of trend weights was necessary to obtain incidence estimates across USA, considering the stratified framework of the NIS database and the dependence on observed frequencies within the database. Two assessments were utilized to assess the projected annual rates of complications.

RESULTS

Between 2010 and 2019, a total of 189,695 patients were estimated to underwent primary elective TSA. Infections, such as pneumonia, respiratory failure or PE, complicated 1.4% (95% CI, 1.52%-1.64%) of TSA operations. The ailments at this period that were most likely to result in pulmonary problems were ulcer (adjusted odds ratio [AOR] = 9.43; 95% CI, 4.99-46.91), pulmonary circulation disorders (AOR = 9.01; 95% CI, 4.56- 31.92), weight loss (AOR = 4.84; 95% CI, 2.15-10.88), fluid and electrolyte disorders (AOR = 3.55; 95% CI, 2.55-4.95), alcohol abuse (AOR = 1.56; 95% CI, 1.08-2.26), congestive heart failure (AOR = 3.09; 95% CI, 1.83-5.24), chronic pulmonary disease (AOR = 2.45; 95% CI, 1.60-3.75), deficiency anaemia (AOR = 1.56; 95% CI, 1.08-2.26), depression (AOR = 1.47; 95% CI, 1.03-2.11) and obesity (AOR = 1.46; 95% CI, 1.01-2.11). A correlation was found between perioperative pulmonary problems and extended LOS (+ 3 days; 95% CI, 2-6) and increased hospitalization costs (= + 20,514 US dollars; 95% CI, 14,109-35,281).

CONCLUSIONS

This investigation primarily aimed to ascertain potential risk factors linked to pulmonary issues that may occur after TSA. The analysis revealed that the pneumonia rates decreased each year, whereas the PE rates remained relatively stable. A noticeable and consistent increase was found in respiratory failure from 2010 to 2019. The findings suggests that individuals who are older (primarily between the ages of 60 and 80 years) and female exhibit increased rates. These factors could help stratify patients and reduce the risk of potential complications. This claim is especially applicable in PE because it is associated with more significant improvements in resource utilization.

摘要

背景

在美国,全肩关节置换术(TSA)位列需要住院治疗的五大手术之一。因此,由于后续肺部问题的出现,美国的医疗系统可能面临相当大的财务压力。本研究旨在全面检查肺部并发症的患病率、影响因素及医学重要性,重点关注美国全肩关节置换术(TSA)后发生的肺炎、呼吸衰竭和肺栓塞(PE)。

方法

利用国家住院患者样本(NIS)对2010年至2019年接受初次择期TSA的所有患者进行调查。TSA后的肺炎、呼吸衰竭和PE被视为肺部后果。比较了有和没有报告围手术期肺部问题患者的住院费用、住院时间、死亡率和患者特征。考虑到NIS数据库的分层框架以及对数据库内观察频率的依赖性,有必要使用趋势权重来获得美国各地的发病率估计值。采用两种评估方法来评估并发症的预计年发生率。

结果

2010年至2019年期间,估计共有189,695例患者接受了初次择期TSA。感染,如肺炎、呼吸衰竭或PE,使1.4%(95%CI,1.52%-1.64%)的TSA手术出现并发症。这一时期最有可能导致肺部问题的疾病是溃疡(调整优势比[AOR]=9.43;95%CI,4.99-46.91)、肺循环障碍(AOR=9.01;95%CI,4.56-31.92)、体重减轻(AOR=4.84;95%CI,2.15-10.88)、体液和电解质紊乱(AOR=3.55;95%CI,2.55-4.95)、酒精滥用(AOR=1.56;95%CI,1.08-2.26)、充血性心力衰竭(AOR=3.09;95%CI,1.83-5.24)、慢性肺病(AOR=2.45;95%CI,1.60-3.75)、缺铁性贫血(AOR=1.56;95%CI,1.08-2.26)、抑郁症(AOR=1.47;95%CI,1.03-2.11)和肥胖症(AOR=1.46;95%CI,1.01-2.11)。发现围手术期肺部问题与住院时间延长(+3天;95%CI,2-6)和住院费用增加(=+20,514美元;95%CI,14,109-35,281)之间存在相关性。

结论

本调查主要旨在确定与TSA后可能发生的肺部问题相关的潜在风险因素。分析显示,肺炎发生率逐年下降,而PE发生率保持相对稳定。2010年至2019年期间,呼吸衰竭出现了明显且持续的上升。研究结果表明,年龄较大(主要在60至80岁之间)和女性的发生率较高。这些因素有助于对患者进行分层,并降低潜在并发症的风险。这一说法在PE方面尤其适用,因为它与资源利用方面更显著的改善相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/f4c91a637148/13741_2024_490_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/90daf34431fe/13741_2024_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/0ae019aa5b1d/13741_2024_490_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/f4c91a637148/13741_2024_490_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/90daf34431fe/13741_2024_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/0ae019aa5b1d/13741_2024_490_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9950/11720511/f4c91a637148/13741_2024_490_Fig3_HTML.jpg

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