Di-Bonaventura Silvia, Gurdiel-Álvarez Francisco, Reina-Varona Álvaro, Pacheco-Barrios Kevin, Molina-Álvarez Miguel, Fernández-Carnero Josué, Ferrer-Peña Raúl
Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Alcorcón, Spain.
International Doctorate School, Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, Spain.
Biol Res Nurs. 2025 Jul;27(3):371-382. doi: 10.1177/10998004251313741. Epub 2025 Jan 9.
This cross-sectional study compared plasma brain-derived neurotrophic factor (BDNF) levels among chronic primary musculoskeletal pain patients, chronic widespread pain patients, and asymptomatic controls. The study included 126 participants aged 18-65, divided into three groups of 42 each. Pain intensity was assessed using a Numeric Rating Scale (NRS), and plasma BDNF levels were measured via ELISA. Differences between groups were evaluated using ANOVA with 2000 bootstrap resamples and a bias-corrected and accelerated method. Results showed significantly higher plasma BDNF levels in chronic widespread pain patients (mean difference [MD] = 0.44; 95% CI = 0.28, 0.62; .001) compared to controls, and higher than in chronic primary musculoskeletal pain patients (MD = 0.83; 95% CI = 0.64, 1.02; .001). Chronic primary musculoskeletal pain patients had lower plasma BDNF levels compared to controls (MD = -0.39; 95% CI = -0.54, -0.24; .001). No significant correlations were observed between plasma BDNF levels and clinical variables. These findings suggest the potential of BDNF as a biomarker to differentiate chronic primary pain conditions.
这项横断面研究比较了慢性原发性肌肉骨骼疼痛患者、慢性广泛性疼痛患者和无症状对照组的血浆脑源性神经营养因子（BDNF）水平。该研究纳入了126名年龄在18至65岁之间的参与者，分为三组，每组42人。使用数字评分量表（NRS）评估疼痛强度，并通过酶联免疫吸附测定法（ELISA）测量血浆BDNF水平。使用带有2000次自抽样重采样以及偏差校正和加速方法的方差分析（ANOVA）评估组间差异。结果显示，与对照组相比，慢性广泛性疼痛患者的血浆BDNF水平显著更高（平均差[MD]=0.44；95%置信区间[CI]=0.28，0.62；P<0.001），且高于慢性原发性肌肉骨骼疼痛患者（MD=0.83；95%CI=0.64，1.02；P<0.001）。与对照组相比，慢性原发性肌肉骨骼疼痛患者的血浆BDNF水平较低（MD=-0.39；95%CI=-0.54，-0.24；P<0.001）。未观察到血浆BDNF水平与临床变量之间存在显著相关性。这些发现表明BDNF作为区分慢性原发性疼痛状况生物标志物的潜力。
