• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中药单体在黑色素瘤发生过程中的研究进展

Research progress of Chinese medicinal monomers in the process of melanoma occurrence.

作者信息

Shang Yan, Zhao Hailong

机构信息

Department of Pathophysiology, Zunyi Medical University, Zunyi, China.

出版信息

Pharm Biol. 2025 Dec;63(1):53-67. doi: 10.1080/13880209.2024.2445695. Epub 2025 Jan 10.

DOI:10.1080/13880209.2024.2445695
PMID:39790031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11727062/
Abstract

CONTEXT

Melanoma's aggressiveness and resistance to radiotherapy highlight an urgent need for innovative treatments. Traditional Chinese medicine (TCM) offers a unique approach through its 'four natures' theory-cold, cool, warm, and hot.

OBJECTIVE

This review aims to explore the potential of TCM's 'four natures' herbal monomers in melanoma treatment, providing an alternative to conventional therapies.

MATERIALS & METHODS: A systematic literature review was conducted by accessing various databases, including Baidu Scholar, PubMed, Science Citation Index Expanded (SCIE), and China National Knowledge Infrastructure (CNKI), to synthesize the most recent findings on traditional Chinese medicine monomers. Furthermore, this review elucidated the mechanisms underlying their role in melanoma retention.

RESULTS

TCM's multi-component, multi-target approach has shown promise in addressing melanoma's complexity, with specific monomers demonstrating the ability to modulate tumor behavior.

DISCUSSION AND CONCLUSIONS

The 'four natures' theory in TCM presents a novel perspective for melanoma treatment, warranting further investigation into its clinical applications and potential integration with modern oncology.

摘要

背景

黑色素瘤的侵袭性和对放疗的抗性凸显了对创新治疗方法的迫切需求。传统中医通过其“四性”理论——寒、凉、温、热，提供了一种独特的方法。

目的

本综述旨在探讨中医“四性”草本单体在黑色素瘤治疗中的潜力，为传统疗法提供替代方案。

材料与方法

通过访问多个数据库进行系统的文献综述，包括百度学术、PubMed、科学引文索引扩展版（SCIE）和中国知网（CNKI），以综合关于中药单体的最新研究结果。此外，本综述阐明了它们在黑色素瘤治疗中作用的潜在机制。

结果

中医的多成分、多靶点方法在应对黑色素瘤的复杂性方面显示出前景，特定单体表现出调节肿瘤行为的能力。

讨论与结论

中医的“四性”理论为黑色素瘤治疗提供了一个新的视角，值得进一步研究其临床应用以及与现代肿瘤学的潜在整合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/ef8a65f6b5ba/IPHB_A_2445695_F0007b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/05a5476188e2/IPHB_A_2445695_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/07d4cea68bdc/IPHB_A_2445695_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/66a9eade0822/IPHB_A_2445695_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/2cb80521813f/IPHB_A_2445695_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/bc851af0356d/IPHB_A_2445695_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/6893063d6b83/IPHB_A_2445695_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/d8c02548f742/IPHB_A_2445695_F0007a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/ef8a65f6b5ba/IPHB_A_2445695_F0007b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/05a5476188e2/IPHB_A_2445695_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/07d4cea68bdc/IPHB_A_2445695_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/66a9eade0822/IPHB_A_2445695_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/2cb80521813f/IPHB_A_2445695_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/bc851af0356d/IPHB_A_2445695_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/6893063d6b83/IPHB_A_2445695_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/d8c02548f742/IPHB_A_2445695_F0007a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176e/11727062/ef8a65f6b5ba/IPHB_A_2445695_F0007b_B.jpg

相似文献

1
Research progress of Chinese medicinal monomers in the process of melanoma occurrence.中药单体在黑色素瘤发生过程中的研究进展
Pharm Biol. 2025 Dec;63(1):53-67. doi: 10.1080/13880209.2024.2445695. Epub 2025 Jan 10.
2
Rabdosia rubescens (Hemsl.) H. Hara: A potent anti-tumor herbal remedy - Botany, phytochemistry, and clinical applications and insights.冬凌草：一种有效的抗肿瘤草药疗法——植物学、植物化学、临床应用及见解
J Ethnopharmacol. 2025 Jan 31;340:119200. doi: 10.1016/j.jep.2024.119200. Epub 2024 Dec 3.
3
Research progress of effective components of traditional Chinese medicine in intervening apoptosis of renal tubular epithelial cells in diabetic kidney disease.中药有效成分干预糖尿病肾病肾小管上皮细胞凋亡的研究进展
J Ethnopharmacol. 2025 May 28;348:119874. doi: 10.1016/j.jep.2025.119874. Epub 2025 Apr 23.
4
Oral traditional Chinese medication for adhesive small bowel obstruction.口服中药治疗粘连性小肠梗阻。
Cochrane Database Syst Rev. 2012 May 16;2012(5):CD008836. doi: 10.1002/14651858.CD008836.pub2.
5
Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers.抗肿瘤中药单体的临床试验分析。
Drug Des Devel Ther. 2024 Jun 5;18:1997-2020. doi: 10.2147/DDDT.S454774. eCollection 2024.
6
Examining patterns of traditional Chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study.考察中医在儿科肿瘤学中的应用模式：系统评价、荟萃分析和数据挖掘研究。
J Integr Med. 2022 Sep;20(5):402-415. doi: 10.1016/j.joim.2022.06.003. Epub 2022 Jun 10.
7
A systematic review: Botany, phytochemistry, traditional uses, pharmacology, toxicology, quality control and pharmacokinetics of Ilex rotunda Thunb.系统评价：冬青属植物的植物学、植物化学、传统用途、药理学、毒理学、质量控制和药代动力学。
J Ethnopharmacol. 2022 Nov 15;298:115419. doi: 10.1016/j.jep.2022.115419. Epub 2022 Jun 30.
8
Research progress on the regulation of interstitial cell of Cajal autophagy and apoptosis crosstalk by traditional Chinese medicine in gastrointestinal motility disorders.中药对胃肠动力障碍中Cajal间质细胞自噬与凋亡相互作用调控的研究进展
J Ethnopharmacol. 2025 Jun 11;351:120128. doi: 10.1016/j.jep.2025.120128.
9
Research Progress of Natural Compounds from Chinese Herbal Medicine in the Treatment of Melanoma.中草药天然化合物治疗黑色素瘤的研究进展
Curr Treat Options Oncol. 2025 May 15. doi: 10.1007/s11864-025-01322-8.
10
Chinese herbal medicine for oesophageal cancer.用于食管癌的中草药。
Cochrane Database Syst Rev. 2016 Jan 22;2016(1):CD004520. doi: 10.1002/14651858.CD004520.pub7.

引用本文的文献

1
Research progress and molecular mechanism of oridonin in the treatment of malignant melanoma.冬凌草甲素治疗恶性黑色素瘤的研究进展及分子机制
Front Oncol. 2025 Jun 17;15:1606325. doi: 10.3389/fonc.2025.1606325. eCollection 2025.

本文引用的文献

1
Maintaining calcium homeostasis as a strategy to alleviate nephrotoxicity caused by evodiamine.维持钙稳态作为减轻吴茱萸碱肾毒性的策略。
Ecotoxicol Environ Saf. 2024 Aug;281:116563. doi: 10.1016/j.ecoenv.2024.116563. Epub 2024 Jun 14.
2
The most recent progress of baicalein in its anti-neoplastic effects and mechanisms.黄芩素在抗肿瘤作用及机制方面的最新进展。
Biomed Pharmacother. 2024 Jul;176:116862. doi: 10.1016/j.biopha.2024.116862. Epub 2024 Jun 7.
3
Evodiamine inhibits growth of vemurafenib drug-resistant melanoma via suppressing IRS4/PI3K/AKT signaling pathway.
吴茱萸碱通过抑制 IRS4/PI3K/AKT 信号通路抑制维莫非尼耐药黑色素瘤的生长。
J Nat Med. 2024 Mar;78(2):342-354. doi: 10.1007/s11418-023-01769-9. Epub 2024 Feb 7.
4
Integrated blood and organ profile analysis to evaluate ameliorative effects of kaempferol on 5-fluorouracil-induced toxicity.综合血液和器官谱分析评价山奈酚对 5- 氟尿嘧啶毒性的改善作用。
Sci Rep. 2024 Jan 29;14(1):2363. doi: 10.1038/s41598-024-52915-6.
5
ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy.ATP1A1是黑色素瘤治疗中一个有前景的新靶点，并且可以被其生理配体蟾毒灵抑制，以恢复靶向治疗的疗效。
Cancer Cell Int. 2024 Jan 4;24(1):8. doi: 10.1186/s12935-023-03196-y.
6
Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis.双氢青蒿素通过影响血管生成来抑制黑色素瘤的迁移和转移。
Phytother Res. 2025 Apr;39(4):1679-1693. doi: 10.1002/ptr.8065. Epub 2023 Nov 19.
7
Natural Compounds, Optimal Combination of Brusatol and Polydatin Promote Anti-Tumor Effect in Breast Cancer by Targeting Nrf2 Signaling Pathway.天然化合物，白头翁素和虎杖苷的最佳组合通过靶向 Nrf2 信号通路促进乳腺癌的抗肿瘤作用。
Int J Mol Sci. 2023 May 5;24(9):8265. doi: 10.3390/ijms24098265.
8
Ginsenoside Rb for overcoming cisplatin-insensitivity of A549/DDP cells in vitro and vivo through the dual-inhibition on two efflux pumps of ABCB1 and PTCH1.人参皂苷 Rb 通过双重抑制 ABCB1 和 PTCH1 两种外排泵克服 A549/DDP 细胞的顺铂耐药性：体内外研究
Phytomedicine. 2023 Jul;115:154776. doi: 10.1016/j.phymed.2023.154776. Epub 2023 Mar 18.
9
HOXB9 a miR-122-5p regulated gene, suppressed the anticancer effects of brusatol by upregulating SCD1 expression in melanoma.HOXB9 是一个受 miR-122-5p 调控的基因，通过上调黑色素瘤中 SCD1 的表达来抑制布瑞他汀的抗癌作用。
Biomed Pharmacother. 2023 Jun;162:114650. doi: 10.1016/j.biopha.2023.114650. Epub 2023 Apr 7.
10
Curcumin in the treatment of liver cancer: From mechanisms of action to nanoformulations.姜黄素治疗肝癌：从作用机制到纳米制剂。
Phytother Res. 2023 Apr;37(4):1624-1639. doi: 10.1002/ptr.7757. Epub 2023 Mar 8.