Cau Riccardo, Saba Luca
Department of Radiology, University of Cagliari, Cagliari, Italy.
Cardiovasc Diagn Ther. 2024 Dec 31;14(6):1186-1201. doi: 10.21037/cdt-24-344. Epub 2024 Nov 12.
Interleukin-6 (IL-6) plays multifaceted roles in cancer and atherosclerosis. Initially recognized for its role in immune response and inflammation, IL-6 promotes tumor progression via the JAK-STAT and MAP kinase pathways and is associated with poor cancer prognoses. In atherosclerosis, IL-6 contributes to endothelial dysfunction and plaque formation. This review highlights the shared inflammatory mechanisms of IL-6 in both diseases and explores the regulatory dynamics of IL-6 signaling, including gene polymorphisms and epigenetic modifications.
Google Scholar, Scopus, and PubMed were searched for English-language articles on IL-6 and those reporting shared pathogenic mechanisms of IL-6 in cancer and atherosclerosis from their inception through June 2024.
The investigation into IL-6's mechanisms in cancer and atherosclerosis reveals the intricate and interconnected nature of inflammatory processes in chronic diseases. The role of IL-6 in both conditions underscores its centrality in disease pathology, particularly through its involvement in inflammation, immune modulation, and cellular proliferation. This commonality highlights IL-6 as a key player linking these seemingly distinct diseases.
Given the shared pathogenic mechanism of IL-6 in cancer and atherosclerosis, this narrative review concludes by emphasizing the therapeutic potential of modulating IL-6 in treating both cancer and atherosclerosis. It advocates for personalized treatment strategies that combine targeted therapies with lifestyle modifications. This holistic approach is considered crucial for effective disease management, given the diverse and complex roles IL-6 plays in these widespread conditions.
白细胞介素-6（IL-6）在癌症和动脉粥样硬化中发挥着多方面作用。IL-6最初因其在免疫反应和炎症中的作用而被认识，它通过JAK-STAT和丝裂原活化蛋白激酶（MAP）途径促进肿瘤进展，并与癌症预后不良相关。在动脉粥样硬化中，IL-6导致内皮功能障碍和斑块形成。本综述强调了IL-6在这两种疾病中共同的炎症机制，并探讨了IL-6信号传导的调控动态，包括基因多态性和表观遗传修饰。
在谷歌学术、Scopus和PubMed数据库中检索自数据库建立至2024年6月期间关于IL-6以及报道IL-6在癌症和动脉粥样硬化中共同致病机制的英文文章。
对IL-6在癌症和动脉粥样硬化中机制的研究揭示了慢性疾病中炎症过程的复杂和相互联系的本质。IL-6在这两种疾病中的作用强调了其在疾病病理学中的核心地位，特别是通过其在炎症、免疫调节和细胞增殖中的作用。这种共性突出了IL-6作为连接这些看似不同疾病的关键因素。
鉴于IL-6在癌症和动脉粥样硬化中存在共同的致病机制，本叙述性综述最后强调了调节IL-6在治疗癌症和动脉粥样硬化方面的治疗潜力。它提倡将靶向治疗与生活方式改变相结合的个性化治疗策略。鉴于IL-6在这些广泛疾病中所起的多样而复杂的作用，这种整体方法被认为对有效管理疾病至关重要。
