Kajiyama Kenta, Taira Akihiro, Takenaka Masaru, Kuroda Koji, Kusano Midori, Nawata Aya, Tanaka Fumihiro
Second Department of Surgery (Chest Surgery), University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Ann Thorac Surg Short Rep. 2022 Aug 5;1(1):121-123. doi: 10.1016/j.atssr.2022.07.004. eCollection 2023 Mar.
Sarcomatoid malignant pleural mesothelioma (MPM) is a highly aggressive malignant tumor. Surgery may not be recommended, and chemotherapy is less effective. More recently, immunotherapy has become a new standard treatment of care for advanced MPM across all histologic subtypes. This reports describes a case of salvage lung-sparing surgery (pleurectomy with decortication) after immunotherapy with nivolumab in combination with ipilimumab for sarcomatoid MPM. The surgical specimen showed that a major pathologic response was achieved with immunotherapy. The present case indicates not only the feasibility of pleurectomy with decortication after immunotherapy but also pathologic evidence of the efficacy of immunotherapy, which provides insight into the treatment of advanced MPM.
肉瘤样恶性胸膜间皮瘤（MPM）是一种侵袭性很强的恶性肿瘤。可能不建议进行手术，化疗效果也较差。最近，免疫疗法已成为所有组织学亚型晚期MPM的新的标准治疗方法。本报告描述了一例在使用纳武单抗联合伊匹单抗治疗肉瘤样MPM后进行挽救性保肺手术（胸膜剥脱术）的病例。手术标本显示免疫疗法取得了主要病理缓解。本病例不仅表明免疫治疗后进行胸膜剥脱术的可行性，还提供了免疫治疗疗效的病理证据，这为晚期MPM的治疗提供了思路。
