Del Vecchio Daniel, Vranis Neil, Alevrogianni Korina, Theodorou Spero
Aesthet Surg J Open Forum. 2024 Nov 19;7:ojae112. doi: 10.1093/asjof/ojae112. eCollection 2025.
Extraction of adipose-derived stem cells (ASCs) from the stromal vascular fraction (SVF) has gained significant attention lately in the realm of regenerative medicine. However, finding highly efficient methods of extraction that also comply with the US regulations has prevented widespread clinical use.
The objective of this study was to evaluate a novel ASC extraction device to quantify viable ASC extraction and processing efficiency.
SVF extracted from abdominal fat samples and processed using a novel shock-assisted viable extraction (SAVE) device was tested for stem-cell count and viability. Additionally, time required for processing was recorded.
Twelve adipose samples were utilized for this study. After a mean time of 3 min, cell count yield ranged of 47,400 to 189,400 of viable regenerative cells per cc, with an average of 122,464 viable regenerative cells per cc.
SAVE is a novel fat-processing technique with high stem-cell extraction that shows promise from a regulatory, yield, time efficiency, and cost perspective.
从基质血管成分（SVF）中提取脂肪来源干细胞（ASC）近来在再生医学领域受到了广泛关注。然而，寻找既高效又符合美国法规的提取方法阻碍了其在临床的广泛应用。
本研究的目的是评估一种新型的ASC提取装置，以量化有活力的ASC提取量和处理效率。
从腹部脂肪样本中提取SVF，并使用一种新型的冲击辅助有活力提取（SAVE）装置进行处理，检测其干细胞数量和活力。此外，记录处理所需时间。
本研究使用了12个脂肪样本。平均3分钟后，每立方厘米有活力的再生细胞计数产量在47400至189400之间，平均每立方厘米有122464个有活力的再生细胞。
SAVE是一种新型的脂肪处理技术，具有高干细胞提取量，从监管、产量、时间效率和成本角度来看都很有前景。
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