Elfarargy Mohamed Shawky, Ahmad Ahmad Roshdy, Elbadry Dalia Hamdy
Department of Pediatrics, College of Medicine, Jouf University, Sakaka, KSA.
Department of Pediatrics, Tanta University, Tanta, Egypt.
Endocr Metab Immune Disord Drug Targets. 2025;25(11):835-847. doi: 10.2174/0118715303325556241127080237.
Neonates exhibit pain responses characterized by various endocrinal changes, including alterations in cortisone and oxytocin serum levels, as well as physiological and emotional reactions. The administration of neonatal pain management leads to the normalization of endocrine hormones, including cortisone and oxytocin, which are affected by the presence of neonatal pain. Diagnosing neonatal pain is complex; however, effective management is essential. An adequate balance should be established between the analgesics used for pain management and their associated side effects. Uncontrolled neonatal pain is correlated with delayed development with increased neurologic insult. This review aims to examine the significance of neonatal pain, along with its clinical and physical manifestations. It also explores strategies for managing neonatal pain, encompassing both pharmacological and non-pharmacological methods, along with the particular medications utilized in pharmacological interventions. This discussion includes various non-pharmacological methods for managing neonatal pain. Additionally, this review examines methods for pain assessment. The aim is to highlight the significance of pain in this vulnerable population and to promote the implementation of diverse management strategies for neonatal pain to prevent serious yet avoidable, adverse effects in neonates.
新生儿表现出以各种内分泌变化为特征的疼痛反应，包括可的松和催产素血清水平的改变，以及生理和情绪反应。新生儿疼痛管理可使受新生儿疼痛影响的内分泌激素（包括可的松和催产素）恢复正常。诊断新生儿疼痛很复杂；然而，有效的管理至关重要。在用于疼痛管理的镇痛药与其相关副作用之间应建立适当的平衡。未控制的新生儿疼痛与发育延迟及神经损伤增加相关。本综述旨在探讨新生儿疼痛的重要性及其临床和身体表现。它还探索了管理新生儿疼痛的策略，包括药理学和非药理学方法，以及药理学干预中使用的特定药物。本次讨论包括各种管理新生儿疼痛的非药理学方法。此外，本综述还研究了疼痛评估方法。目的是强调疼痛在这一脆弱人群中的重要性，并促进实施多种新生儿疼痛管理策略，以预防新生儿严重但可避免的不良影响。
